Aortic Remodeling
Aortic Remodeling - Related Videos
02:37
Surgical Aortic Debanding: A Procedure to Study Left Ventricular Reverse Remodeling in Murine Model of Aortic Constriction
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2025
This video demonstrates the technique of aortic debanding, which can lead to reverse remodeling to limit the progression towards heart failure in a murine model. Post debanding, a significant reduction of ventricular afterload triggers regression of ventricular hypertrophy and fibrosis, causing a recovery in cardiac function.
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
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Cited by 3 •
2013
Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion pathobiology.
02:54
Nucleosome Remodeling
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2020
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure. Nucleosome remodeling complex Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
07:26
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
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Cited by 2 •
2021
Here we describe a step-by-step protocol of surgical aorta debanding in the well-established mice model of aortic-constriction. This procedure not only allows studying the mechanisms underlying the left ventricular reverse remodeling and regression of hypertrophy but also to test novel therapeutic options that might accelerate myocardial recovery.
07:31
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
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Cited by 26 •
2016
A rat model of abdominal aortic constriction that induces cardiac hypertrophy and remodeling is described. An efficient, highly-reproducible, and minimally-invasive method is used to provide a simple yet useful platform for research in myocardial hypertrophy and dysfunction.
FAQs
Aortic remodeling reflects coordinated changes in several wall components rather than a single structural response. Altered endothelial signaling can influence vascular smooth muscle cell behavior, while inflammation and extracellular matrix turnover modify the tissue framework. Together, these processes can change wall thickness and composition, helping explain why similar hemodynamic stresses may produce different structural outcomes in different disease settings.
Blood flow, pressure, and mechanical stress provide the main conditions that initiate changes in the aortic wall. When these forces change, endothelial signaling and vascular smooth muscle cell activity can also change, followed by adjustments in inflammation and extracellular matrix turnover. The resulting structural response may alter aortic diameter, wall thickness, or tissue composition.
Adaptive remodeling allows the aorta to accommodate altered hemodynamic conditions without necessarily compromising its structure. Maladaptive remodeling, in contrast, can weaken the wall as tissue composition and extracellular matrix turnover change in an unfavorable direction. This distinction is clinically important because maladaptive changes are associated with aneurysm formation, dissection, and progression of atherosclerosis.
Extracellular matrix turnover changes the material framework that supports the aortic wall. In combination with inflammation and altered vascular smooth muscle cell behavior, it can modify wall thickness and tissue composition. If these changes become maladaptive, the wall may weaken, providing a biological connection between remodeling processes and structural complications such as aneurysm formation or dissection.
Imaging-based monitoring can follow structural features that change during remodeling, including aortic diameter and wall thickness. It may also help assess differences in tissue composition as the condition evolves. These observations support risk assessment by linking measurable changes in the aortic wall with altered mechanical conditions and the possibility of disease progression.
Together, these measurements provide complementary information about how the aortic wall is adapting. Diameter reflects an overall structural change, wall thickness indicates another aspect of wall response, and tissue composition helps describe changes within the wall itself. Interpreting them together can support monitoring and help identify remodeling patterns associated with vascular disease.
Research connects mechanical conditions with endothelial signaling, vascular smooth muscle cell behavior, inflammation, and extracellular matrix turnover. This framework helps investigators identify possible targets for therapies aimed at mechanical stress and vascular biology. The broader goal is to improve understanding of aneurysm formation, dissection, atherosclerosis progression, and the factors that influence vascular risk.