Human Tongue Biopsy
Human Tongue Biopsy - Related Videos
09:39
Technique to Collect Fungiform (Taste) Papillae from Human Tongue
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Cited by 30 •
2010
Knowledge of molecular mechanisms underlying gustatory transduction has recently enjoyed significant advances, largely due to using animal models. However, the wide diversity in taste sensitivity and specificity among mammals warrants studies in human tissue. We describe a biopsy technique to collect living taste cells from the papillae on human tongue.
06:33
Establishment of Human Epithelial Enteroids and Colonoids from Whole Tissue and Biopsy
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Cited by 132 •
2015
We describe a method to establish human enteroids from small intestinal crypts and colonoids from colon crypts collected from both surgical tissue and biopsies. In this methodological article, we present the culture modalities that are essential for the successful growth and maintenance of human enteroids and colonoids.
01:01
Tongue
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2024
The human tongue is a fascinating and complex organ, responsible for various essential functions such as swallowing, speech, and taste. It is also subject to various conditions and diseases. In this article, we delve into the anatomy of the tongue, its roles, and some common conditions that can affect it. Anatomical Position in the Oral Cavity The tongue is located within the oral cavity, also known as the mouth. It is attached to the floor of the mouth by a fold of mucous membrane called the...
11:22
Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
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Cited by 5 •
2013
In order to study the changes of nociceptive intraepidermal nerve fibers (IENFs) in painful neuropathies (PN), we developed protocols that could directly examine three-dimensional morphological changes observed in nociceptive IENFs. Three-dimensional analysis of IENFs has the potential to evaluate the morphological changes of IENF in PN.
04:51
Fabrication of Extracellular Matrix from Mouse Model: An Effective Procedure to Prepare Decellularized Tongue Extracellular Matrix from Murine Tongue
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2023
This video demonstrates the preparation of the murine tongue extracellular matrix by using the decellularization method, which involves exposing the harvested tongue to a series of physical, chemical, and enzymatic treatments. The resulting TEM scaffold retains its native extracellular matrix composition, removing the cellular components.
FAQs
The diagnostic value comes from linking a visible abnormality to tissue architecture and cell appearance. Microscopic assessment can show patterns compatible with benign disease, infection, inflammation, dysplasia, or malignancy, rather than relying only on how a lesion looks clinically. This tissue-level distinction helps clinicians explain persistent tongue changes and select an appropriate management plan.
These techniques provide different ways to collect a tissue sample, allowing the clinician to select a sampling approach for the tongue abnormality being evaluated. The essential diagnostic requirement is obtaining representative tissue that can be preserved and examined. The technique describes how the specimen was collected, while microscopic findings determine its diagnostic significance.
Preservation, sectioning, and staining prepare collected tissue for microscopic examination. The pathologist needs a specimen that can be evaluated for cellular and structural features. Together, these steps make the tissue suitable for comparison across diagnostic categories such as infection, inflammation, dysplasia, benign change, or malignancy, supporting a more informed interpretation.
Clinical examination and imaging can identify or characterize an abnormal tongue area, but they may not explain its underlying cause. Biopsy supplies tissue-based evidence by allowing direct evaluation of cellular and structural features. This additional level of information helps distinguish conditions that may appear similar during examination or on imaging alone.
After local anesthesia, the clinician collects tissue using an incisional, excisional, or punch technique. The specimen is then preserved, sectioned, and stained before microscopic review by a pathologist. This sequence connects the bedside sampling step with laboratory assessment, so the final interpretation is based on the tissue’s cellular and structural features.
A biopsy may be considered for a persistent lesion, ulcer, mass, or other abnormal tongue change, particularly when clinical examination or imaging does not explain the finding. Sampling provides evidence that can help determine whether the abnormality reflects a benign condition, infection, inflammation, dysplasia, or malignancy.
Findings guide treatment planning by clarifying the pathologic category of the tongue abnormality. Evidence of benign change, infection, inflammation, dysplasia, or malignancy can lead clinicians toward different management considerations. The value lies in replacing an uncertain clinical impression with microscopic information that directly describes the specimen’s cellular and structural characteristics.