Specimen Extraction

Specimen extraction is the controlled collection and removal of biological material, such as blood, tissue, urine, or swabs, for diagnostic testing, monitoring, or research. In medicine, clinicians select an appropriate sampling site and technique, use aseptic handling to limit contamination, and place the specimen in a suitable container or transport medium so its cellular, chemical, or microbial properties remain stable. Proper extraction supports histopathology, microbiology, hematology, and molecular analysis, while errors in collection, labeling, or transport can compromise results. Standardized procedures therefore improve diagnostic accuracy, patient safety, and the reliability of clinical investigations.

Specimen Extraction - Related Videos

Research

JoVE Journal - Cancer Research

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision

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2025

Robot-assisted natural orifice specimen extraction surgery is a minimally invasive technique that combines robotic precision with natural orifice specimen extraction. A 67-year-old patient successfully underwent the procedure in 290 min, with minimal bleeding and no residual cancer. This approach minimized abdominal trauma, reduced complications, and enabled a quick recovery.

Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry

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2025

This protocol enables efficient histone extraction from various clinical samples for subsequent post-translational modification analysis by LC-MS/MS. By facilitating robust detection of key histone modifications, it serves as a valuable tool for comprehensive epigenetic profiling in large clinical cohorts.

Extracellular Vesicle Extraction: A Technique to Isolate Extracellular Vesicles from Whole Tissue Specimens Using Differential Centrifugation

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2023

This video describes the technique of extracting extracellular vesicles from fresh or frozen tissues. The isolated extracellular vesicles can be used for further analysis to uncover their significant roles in disease pathogenesis.

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

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Cited by 5 •

2024

A procedure to extract cell-free DNA from vitreous and aqueous humor to perform molecular studies for diagnosing vitreoretinal lymphoma is established here. The method offers the ability to concurrently extract DNA from the cellular component of the sample or to reserve it for ancillary testing.

Brain Banking: Making the Most of your Research Specimens

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Cited by 21 •

2009

Brain banking and systematic sampling of biological material provides the basis for unbiased stereology and maximizes the potential data obtained from each specimen.

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