Deep Brain Electrode

A deep brain electrode is a slender implanted device that records neural activity or delivers electrical stimulation within precisely targeted brain regions, enabling direct study and modulation of neural circuits. Positioned using anatomical or imaging guidance, its contacts detect local voltage changes or generate controlled electrical fields that influence nearby neurons and network activity. In neuroscience, deep brain electrodes support investigations of brain function, neural communication, and circuit mechanisms, while clinical systems use related technology for conditions such as movement disorders. These electrodes also contribute to brain-computer interfaces and research into therapies for neurological and psychiatric disorders.

Deep Brain Electrode - Related Videos

Research

JoVE Journal - Neuroscience

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

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Cited by 8 •

2015

A method for implanting electrodes into the subthalamic nucleus (STN) of rats is described. Better localization of the STN was achieved by using a microrecording system. Furthermore, a stimulation set-up is presented that is characterized by long-lasting connections between the head of the animal and the stimulator.

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

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Cited by 21 •

2016

Non-restraining EEG radiotelemetry is a valuable methodological approach to record in vivo long-term electroencephalograms from freely moving rodents. This detailed protocol describes stereotaxic epidural and deep intracerebral electrode placement in different brain regions in order to obtain reliable recordings of CNS rhythmicity and CNS related behavioral stages.

Deep Brain Stimulation with Simultaneous fMRI in Rodents

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Cited by 21 •

2014

This protocol describes a standard method for simultaneous functional magnetic resonance imaging and deep brain stimulation in the rodent. The combined use of these experimental tools allows for the exploration of global downstream activity in response to electrical stimulation at virtually any brain target.

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

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Cited by 9 •

2015

The mechanism underlying the therapeutic effects of Deep Brain Stimulation (DBS) surgery needs investigation. The methods presented in this manuscript describe an experimental approach to examine the cellular events triggered by DBS by analyzing the gene expression profile of candidate genes that can facilitate neurogenesis post DBS surgery.

Deep Brain Stimulation as a Treatment for Drug Addiction in a Rat Model

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2025

Source: Batra, V., et al. A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration. J. Vis. Exp. (2016).This video demonstrates a rat model of drug addiction in which the animal self-administers intravenous methamphetamine by pressing a lever, leading to compulsive drug-seeking behavior driven by dopamine release in the nucleus accumbens. To counteract this, the rat undergoes deep brain stimulation (DBS) via an implanted bipolar...

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