Migrating Myoelectric Complex
Migrating Myoelectric Complex - Related Videos
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Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
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Cited by 5 •
2016
MRP4 regulates various cyclic nucleotide-dependent signaling events including a recently elucidated role in cell migration. We describe a direct, but multifaceted approach to unravel the downstream molecular targets of MRP4 resulting in identification of a unique MRP4 interactome that plays key roles in the fine-tuned regulation of fibroblast migration.
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Mobility Shift Affinity Capillary Electrophoresis: A Method to Analyze Sample-Ligand Interactions Depending on Differential Migration of Protein-Ligand Complexes
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This video describes the method to analyze protein-ligand interaction by mobility-shift affinity capillary electrophoresis. This method can be used for characterizing the binding behavior of a protein with various charged ligands.
08:52
An Introduction to Cell Motility and Migration
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2023
Cell motility and migration play important roles in both normal biology and in disease. On one hand, migration allows cells to generate complex tissues and organs during development, but on the other hand, the same mechanisms are used by tumor cells to move and spread in a process known as cancer metastasis. One of the primary cellular machineries that make cell movement possible is an intracellular network of myosin and actin molecules, together known as “actomyosin”, which creates a...
08:24
The Transwell Migration Assay
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2023
Cells migration in response to chemical cues is crucial to development, immunity and disease states such as cancer. To quantify cell migration, a simple assay was developed in 1961 by Dr. Stephen Boyden, which is now known as the transwell migration assay or Boyden chamber assay. This set-up consists an insert which separates the wells of a multiwell plate into top and bottom compartments. Cells whose migration is to be studied are seeded into the top compartment and the chemoattractant...
00:53
Migration
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2025
Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters. Why Animals Migrate For...
FAQs
The phases differ in the strength and coordination of contractions as activity moves through the gastrointestinal tract. A particularly powerful phase produces organized contractions that are important for clearing residual material during fasting. Examining when this phase appears and how strongly it propagates helps distinguish normal fasting motility from altered patterns caused by pharmacological intervention.
Generation and propagation depend on the interaction of gastrointestinal smooth muscle, enteric nerves, and signaling molecules. These elements coordinate electrical activity with contraction, allowing the pattern to travel rather than remain localized. Because several control levels contribute, a drug can change MMC behavior by affecting muscle activity, neural regulation, or signaling pathways involved in gastrointestinal motility.
Motilin agonists and opioids provide contrasting pharmacological effects on MMC activity. Motilin agonists stimulate contractions, whereas opioids suppress intestinal activity. Comparing these responses helps researchers identify how agents shift the balance between coordinated propulsion and reduced motility, making the MMC useful for investigating both pro-motility effects and drug-induced gastrointestinal slowing.
The powerful phase matters because it represents the most coordinated contractile activity within the fasting pattern. Changes in this phase can indicate that a treatment has modified gastrointestinal motor function, rather than merely changing isolated muscle contractions. This makes it particularly relevant when evaluating whether a pharmacological agent promotes or suppresses organized intestinal activity.
It serves as a physiological model for testing how drugs alter gastrointestinal motility during fasting. Investigators can focus on changes in electrical and contractile activity and on the movement of the pattern through the stomach and small intestine. These observations help characterize drug actions relevant to delayed gastric emptying, dysmotility, and medication-related gastrointestinal disorders.
Findings can connect altered fasting motor activity with dysmotility and delayed gastric emptying, while also clarifying how medications produce gastrointestinal effects. The model is therefore relevant beyond normal physiology: it supports pharmacology research on agents that stimulate contractions, agents that suppress intestinal activity, and disorders in which coordinated movement is disrupted.