Unresolved Grief

Unresolved grief is a persistent difficulty adapting to a significant loss, in which mourning remains emotionally or functionally disruptive rather than gradually becoming integrated into a person’s life. It can involve sustained yearning, sadness, guilt, anger, avoidance, or difficulty accepting the loss, often maintained by repeated rumination, painful reminders, or withdrawal from supportive relationships. In psychology, recognizing these patterns helps distinguish expected variations in bereavement from grief that warrants additional assessment and support. Grief-focused counseling and psychotherapy can address loss-related thoughts, emotional avoidance, coping strategies, and social connection, helping individuals process the loss and restore daily functioning.

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Research

JoVE Journal - Medicine

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

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Cited by 11 •

2015

Although Candida infection models are available to study host immune resistance, a model to study T cell mediated immunopathology in the context of Candida infection is absent. Here we describe a method to establish Th17 immunopathology associated with oral Candida infection in immunodeficient mice.

Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

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Cited by 2 •

2008

Current HIV-1 strategies act to suppress the viral life cycle but do not effectively eradicate infection. Here, we demonstrate that an engineered recombinase can efficiently excise integrated HIV-1 proviral DNA from the genome of infected cells.

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

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Cited by 88 •

2015

The unpredictable chronic mild stress (UCMS) protocol is a validated method for studying behavioral and physiological changes associated with chronic stress and depressive symptoms. Eight weeks of imposition of the UCMS protocol induces behavioral changes and poor health outcomes in rodents of either gender.

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

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Cited by 5 •

2011

This article provides an overview of a multi-modal approach to mild traumatic brain injury diagnosis and recovery in youth. This approach combines neuropsychological testing with functional magnetic resonance imaging and the Head Impact Telemetry System to monitor the relationship between head impacts and brain activity during cognitive testing.

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

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Cited by 22 •

2015

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.

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