Intermittent Infusion

Intermittent infusion is a method of administering medication or fluid at scheduled intervals rather than continuously, allowing treatment to be delivered in distinct doses. In clinical practice, a prescribed volume enters the patient through an infusion device over a defined period, followed by a pause before the next dose; this timing shapes drug exposure and supports controlled delivery. Intermittent infusion is commonly used when therapy requires repeated intravenous doses, such as antimicrobial treatment, and can help coordinate dosing with patient monitoring and other care. Understanding infusion rate, dose interval, and treatment duration is essential for safe, effective clinical administration.

Intermittent Infusion - Related Videos

Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

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2025

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Preparing and Administering Intermittent Intravenous Medications with an Infusion Pump

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2017

Source: Madeline Lassche, MSNEd, RN and Katie Baraki, MSN, RN, College of Nursing, University of Utah, UT Primary intermittent intravenous (IV) infusions are delivered alone as volume-controlled infusions, while secondary infusions are delivered with another IV fluid, usually maintenance fluids. Intermittent infusions are delivered over a specific amount of time, which is dictated by the type of medication, such as IV antibiotics. High-volume IV medications, anywhere from 50- to 500-mL...

Research

JoVE Journal - Medicine

A Model of Chronic Nutrient Infusion in the Rat

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Cited by 1 •

2013

A protocol for chronic infusions of glucose and Intralipid in rats is described. This model can be used to study the impact of nutrient excess on organ function and physiological parameters.

Research

JoVE Journal - Medicine
Free Sample

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

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Cited by 11 •

2016

To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

Controlled Infusion of Radiopharmaceutical Agent Using a Peristaltic Pump

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2025

Source: Léa Rubira1, Hélène Sturer1, Louise Combette1, Sandra Santini1, Stéphane Renaud1, Cyril Fersing1,21Nuclear medicine department, Institut régional du Cancer de Montpellier (ICM), Univ Montpellier, 2IBMM, Univ Montpellier, CNRS, ENSCMThis video demonstrates the safe, controlled infusion of a radiopharmaceutical using a peristaltic pump with a dual-line cassette system. The setup includes connecting saline and infusion lines, positioning the shielded vial, and initiating simultaneous...

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