Joint Implant Infection
Joint Implant Infection - Related Videos
07:02
Animal Model of Implant-Associated Infections in Mice
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2025
The present protocol describes a mouse model employing subcutaneous dorsal implantation to investigate implant-associated infections, enabling comprehensive investigation of pathophysiological mechanisms and supporting the development of diagnostic criteria with targeted therapeutic strategies.
18:40
Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
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Cited by 19 •
2014
Combined optical and μCT imaging in a mouse model of orthopaedic implant infection, utilizing a bioluminescent engineered strain of Staphylococcus aureus, provided the capability to noninvasively and longitudinally monitor the dynamics of the bacterial infection, as well as the corresponding inflammatory response and anatomical changes in the bone.
03:12
In Vivo Analysis of Implant-Associated Bacterial Infections Using Zebrafish Embryos
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2025
Source: Zhang, X. et. al., A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection. J. Vis. Exp. (2019)This video demonstrates a zebrafish embryo model for studying infections linked to implanted biomaterials. Injecting Staphylococcus aureus with polystyrene microspheres enhances bacterial survival, confirming the infection-promoting role of implanted materials.
11:22
Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Cited by 32 •
2013
An experimental technique for the treatment of osteochondral defects in the rabbit's knee joint is described. The implantation of allogeneic mesenchymal stem cells into osteochondral defects provides a promising development in the field of tissue engineering. The preparation of fibrin-cell-clots in vitro offers a standardized method for implantation.
04:37
A Periprosthetic Joint Candida albicans Infection Model in Mouse
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2024
Periprosthetic joint infection (PJI) caused by dangerous pathogens is common in clinical orthopedics. Existing animal models cannot accurately simulate the actual situation of PJI. Here, we established a Candida albicans biofilm-associated PJI mouse model to research and develop new therapeutics for PJI.
FAQs
Biofilm formation changes the infection from a freely exposed microbial presence into a protected community attached to the implant surface. This protective structure can limit immune clearance and reduce the effectiveness of antimicrobial treatment. As a result, infection may persist around the artificial joint, contributing to inflammation, impaired implant function, and a more difficult recovery.
Host-pathogen interactions determine how microbial persistence and the immune response affect surrounding tissues. Microorganisms can remain associated with the implant while inflammation develops in nearby bone and soft tissue. Studying this balance helps explain why infection can compromise implant function and why both microbial control and management of tissue inflammation matter when planning care.
Joint Implant Infection may begin when microorganisms are introduced during surgery or when they reach the implant later through the bloodstream. These routes represent different points at which infection can arise, but both can lead to microbial attachment, biofilm formation, and inflammation around the implant. Recognizing the route supports interpretation of the clinical and microbiological picture.
Evaluation combines clinical assessment, imaging, and microbiological testing rather than relying on a single source of information. Clinical findings help identify a concerning recovery pattern, imaging examines the implant and surrounding region, and microbiological testing investigates the infectious cause. Together, these approaches support a more informed judgment about the presence and extent of infection.
Treatment decisions depend on the infection and the condition of the implant and surrounding tissues, as reflected by available clinical, imaging, and microbiological information. Options described for this condition include antimicrobial therapy, debridement, implant retention, and revision. Selecting among them requires matching microbial control with the need to preserve function or replace a compromised implant.
Preventing infection is important because microbial growth around an artificial joint can trigger inflammation, interfere with implant function, and complicate recovery. Prevention therefore supports more durable arthroplasty outcomes by reducing the likelihood that host-pathogen interactions will progress to clinically significant implant damage. This goal complements diagnosis and treatment by addressing infection before these complications develop.
Within Immunology and Infection, this topic provides a model for studying how foreign surfaces, microorganisms, and host tissues interact. That perspective connects microbial adhesion and biofilm-associated persistence with inflammatory effects in bone and soft tissue. It also supports research aimed at improving diagnosis, treatment selection, infection prevention, and long-term outcomes after arthroplasty.