変形能と赤血球による血液中赤血球の不均一性を測定
15.1K 回視聴
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51 件の引用
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09:12 分
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2018年1月12日
DOI :10.3791/56910-v
2018年1月12日
•15.1K 回視聴
Nermi L. Parrow*1 , Pierre-Christian Violet*2 , Hongbin Tu2 , James Nichols3 , Corinne A. Pittman4 , Courtney Fitzhugh4 , Robert E. Fleming1,5 , Narla Mohandas6 , John F. Tisdale3 , Mark Levine2
1Department of Pediatrics, Saint Louis University School of Medicine, 2Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 3Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 4Sickle Cell Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 5Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 6Red Cell Physiology Laboratory, New York Blood Center
* These authors contributed equally
赤血球赤血球変形能と細胞の不均一性を測定する技術をご紹介します。これらのテクニックは、赤血球変形能の一般的な調査および鎌状細胞貧血症などの循環の両方の剛性と変形赤血球の存在によって特徴づけられる血液の疾患の特定の調査に適用されます。
Chapters in this video
0:05
Title
1:05
Ektacytometer Set-up
1:48
Measuring Deformability as a Function of Increasing Shear Stress
4:10
Measuring Cellular Heterogeneity
5:20
Osmotic Gradient Ektacytometry
7:16
Results: Diffraction Pattern Distortion and Relationship to Hemoglobin
8:41
Conclusion
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