Vascular Morphology
Vascular Morphology - Related Videos
09:33
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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Cited by 16 •
2015
The present article describes the methodological considerations for several non-invasive assessments of vascular function and morphology that are commonly used in medical research to assess different stages of atherosclerosis.
09:12
Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling
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2026
This protocol includes a step-by-step workflow for calcified vascular specimens: tissue handling, decalcification, RNA validation, calcification level detection, and region-of-interest selection strategies on the Nanostring GeoMx Digital Spatial Profiler (DSP). The goal is to present a comprehensive method for preserving vascular tissue morphology and RNA for reliable spatial transcriptomic analysis.
05:14
Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
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Cited by 5 •
2023
Currently, fluorescein angiography (FA) is the preferred method for identifying leakage patterns in animal models of choroidal neovascularization (CNV). However, FA does not provide information about vascular morphology. This protocol outlines the use of indocyanine green angiography (ICGA) to characterize different lesion types of laser-induced CNV in mouse models.
08:18
Engineered Vascularized Muscle Flap
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Cited by 6 •
2016
To date, thick tissue defects are typically reconstructed by applying autologous tissue flaps or engineered tissues. In this protocol, we present a new method for engineering vascularized tissue flap bearing an autologous pedicle, to serve as a substitute to autologous flaps.
11:10
Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice
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Cited by 3 •
2016
Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.
FAQs
Fluid shear stress provides a mechanical signal that interacts with vascular cells and can influence vessel organization and structural variation. This relationship helps explain why vessel geometry cannot be interpreted independently of blood flow. In bioengineering, considering shear-related effects supports more realistic analyses of engineered vessels and models intended to reproduce living transport conditions.
Angiogenesis and remodeling are structural processes that help produce variation in vessel networks over time. Their effects can appear in features such as branching patterns, vessel diameter, wall thickness, and spatial arrangement. Examining these features together allows researchers to relate vascular development and adaptation to the organization of networks found in tissues.
Vessel diameter and branching patterns provide structural information that can be linked to blood flow and tissue function. Along with wall thickness and spatial arrangement, they help describe how a vascular network is organized rather than treating vessels as isolated tubes. This connection is useful when interpreting transport through living systems or engineered tissue models.
Researchers characterize vascular morphology using microscopy, imaging, and quantitative analysis. These approaches can document vessel diameter, branching patterns, wall thickness, and the spatial arrangement of networks. Combining visual observations with measurements makes it possible to compare vascular structures, assess engineered constructs, and connect observed geometry with transport or functional behavior.
Vascular morphology guides the design of vascularized tissues by providing structural criteria for organizing vessel networks. Researchers can examine how vessel geometry and arrangement relate to tissue function, then use that information when developing engineered models. The resulting designs aim to represent vascular organization more realistically and support analysis of transport within living-system-inspired constructs.
Measurements of vessel diameter, branching, wall thickness, and spatial arrangement provide structural outcomes for evaluating engineered grafts and related medical devices. Comparing these features with blood-flow relationships and tissue-function requirements helps identify whether a design represents physiologically relevant organization. The same analysis can also inform organ models intended to reproduce aspects of living vascular systems.