Drug Transport Alteration
Drug Transport Alteration - Related Videos
13:17
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
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Cited by 48 •
2015
Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.
18:57
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Cited by 58 •
2013
Many therapeutic applications require safe and efficient transport of drug carriers and their cargoes across cellular barriers in the body. This article describes an adaptation of established methods to evaluate the rate and mechanism of transport of drug nanocarriers (NCs) across cellular barriers, such as the gastrointestinal (GI) epithelium.
01:24
Cellular Membranes and Drug Transport
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2024
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange. Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
01:16
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
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2026
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
01:14
Hepatic Drug Clearance: Role of Transporters
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2025
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
FAQs
The balance between influx and efflux determines how much compound enters a cell and how much leaves it. Increased influx or reduced efflux can raise intracellular concentrations, whereas reduced influx or enhanced efflux can lower them. These shifts may change the compound’s biological effect, tissue exposure, and overall treatment response.
Changing the amount of a transporter can modify compound movement across cellular membranes. If one compound affects transporter activity or expression, another compound may reach different intracellular or tissue concentrations than expected. Such changes help explain why individuals can experience different responses, altered bioavailability, or changes in drug clearance under otherwise similar treatment conditions.
A transport change can influence absorption, distribution, cellular entry, or removal, so its consequences depend on where the altered process occurs. Changes affecting cellular uptake may primarily modify intracellular exposure, while changes associated with removal can influence clearance. Considering the affected transport step helps connect transporter behavior with the resulting pharmacological outcome.
Experimental investigations can examine genetic, cellular, and environmental factors that reshape transporter function. Researchers may assess whether these factors change transporter activity or expression and then relate those changes to compound movement or intracellular concentration. This approach helps distinguish sources of variable exposure and clarifies why the same compound may behave differently across biological settings.
Transporter-function studies compare how a compound moves across cellular membranes under different biological conditions. Measurements can focus on transporter activity or expression and on resulting changes in intracellular concentration, bioavailability, or clearance. Interpreting these outcomes together helps identify whether altered transport contributes to changed exposure, interactions, or treatment response.
Understanding transporter-related changes helps researchers anticipate how compounds may move into cells, distribute through tissues, or be removed from the body. The resulting information can support drug design by identifying transport behavior that affects exposure and can strengthen safety assessment by revealing conditions that may alter concentrations or produce unexpected responses.