Ascending Aortic Banding
Ascending Aortic Banding - Related Videos
10:18
Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
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Cited by 17 •
2014
We describe a stepwise procedure for creating pressure overload and left ventricular hypertrophy in Wistar rats by constriction of the ascending aorta using a small metallic clip. This model is extensively used for studying remodeling changes during cardiac hypertrophy and for identifying and evaluating strategies for regression of such changes.
04:38
Transverse Aortic Arch Banding in Mouse Model: A Minimally Invasive Technique in Mice for Induction of High Pressure in the Left Ventricle
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2025
In this video, we demonstrate an experimental protocol for minimally invasive transverse aortic constriction in mice to examine pressure overload-induced heart failure.
10:08
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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Cited by 10 •
2014
We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.
02:37
Surgical Aortic Debanding: A Procedure to Study Left Ventricular Reverse Remodeling in Murine Model of Aortic Constriction
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2025
This video demonstrates the technique of aortic debanding, which can lead to reverse remodeling to limit the progression towards heart failure in a murine model. Post debanding, a significant reduction of ventricular afterload triggers regression of ventricular hypertrophy and fibrosis, causing a recovery in cardiac function.
09:24
O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
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Cited by 1 •
2022
The present protocol describes a new technique of aortic banding in mice to induce pressure overload cardiac hypertrophy. For banding, a rubber ring with a fixed inner diameter is used. This new technique promises less variance and more reproducible data for future experiments.
FAQs
The band raises left ventricular afterload, meaning the ventricle must generate more pressure before blood can leave through the narrowed aortic segment. This increased pressure demand changes the mechanical workload imposed on the heart and provides a controlled way to study how ventricular tissue responds to sustained pressure stress.
Compensatory hypertrophy is an early structural response to the increased pressure demand. By becoming thicker, the ventricular wall adapts to the greater workload imposed by the narrowed aorta. This response can help investigators distinguish an initial adaptation from later remodeling or functional deterioration as the pressure burden continues.
Persistent overload can move the heart beyond compensation and lead to progressive ventricular remodeling or failure. This time-dependent transition is important because it allows researchers to investigate disease progression rather than examining hypertrophy as an isolated endpoint. The model therefore connects an imposed mechanical stress with worsening cardiac outcomes.
The model supports examination of molecular and functional changes that accompany pressure-overload disease. Researchers can follow the development of hypertrophy, assess remodeling, and identify changes associated with declining cardiac performance or heart failure. These complementary outcomes help relate structural adaptation to the broader progression of cardiovascular disease.
The essential procedural sequence is to place a constrictive band around the ascending aorta and create controlled narrowing. This restriction establishes pressure overload for the left ventricle, allowing investigators to examine responses under a defined mechanical challenge. Because the model is surgical and controlled, it can support consistent study of pressure-related cardiac adaptation.
In cardiovascular research, the model links a defined mechanical stress to measurable disease progression. Investigators can examine molecular and functional changes as hypertrophy develops, remodeling emerges, or failure follows persistent overload. Those observations support evaluation of potential treatments aimed at limiting hypertrophy, altering remodeling, or preventing progression toward heart failure.