Donor Lung Evaluation
Donor Lung Evaluation - Related Videos
07:28
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
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2024
This protocol describes a new method for effectively reconstructing donor atrial cuff anterior wall defects during lung transplantation through the rotation of the donor posterior atrial flap.
05:49
Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
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Cited by 5 •
2023
Here, we describe the necessary steps for establishing a rat EVLP model and show the inflammatory profile associated with the perfused lungs. The aim is to propagate knowledge and experiences about the rat EVLP model, enabling the integral understanding of the biological responses associated with that revolutionary technique.
07:32
Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
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Cited by 32 •
2010
Early embryonic lung organ culture is a very useful system to study epithelial-mesenchymal interactions. Both epithelial and mesenchymal morphogenesis proceeds under specific conditions that can be readily manipulated in this system.
07:17
Single Port Donor Nephrectomy
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Cited by 5 •
2011
Single port laparoscopic surgery is changing the standard of care in surgical care like nothing since the laparoscopic technique was introduced 20 years ago. We present out technique of single port donor nephrectomy using the Gelpoint device. We have successfully performed this surgery in 100 patients.
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
FAQs
No single measurement determines suitability. Clinicians compare donor history, chest imaging, pulmonary function, oxygenation, bronchoscopy, microbiology, and direct inspection of the airways and tissue. Agreement among these sources can strengthen confidence in organ quality, while discordant findings prompt closer consideration of possible edema, aspiration, infection, trauma, or impaired gas exchange before acceptance or decline.
These data provide functional evidence about how effectively the lungs exchange gases and perform pulmonary work. Their interpretation alongside imaging and direct observations helps distinguish an apparently acceptable organ from one with clinically important impairment. This combined assessment supports a more informed judgment about suitability rather than relying on structural findings or donor history alone.
Each finding can signal a different concern about lung quality or safety. Edema and aspiration may affect the tissue or airways, infection raises microbiological concerns, and trauma may indicate structural injury. Because these problems are examined through complementary clinical and procedural evidence, their presence is weighed with functional results and the recipient’s circumstances when deciding whether to proceed.
Acceptance is a clinical balance rather than an isolated rating of the organ. A donor lung’s observed condition is considered together with how urgently the recipient needs transplantation and whether the donor-recipient pairing is compatible. This context allows clinicians to make transparent decisions, identify risks that require perioperative planning, and avoid treating every organ or recipient situation as equivalent.
The workflow begins with review of donor history, followed by chest imaging and assessment of pulmonary function and oxygenation. Clinicians then incorporate bronchoscopy, microbiology, and direct inspection of the airways and tissue. Findings are synthesized to identify edema, aspiration, infection, trauma, or impaired gas exchange, after which the team accepts or declines the lungs and prepares for the transplant setting.
Assessment draws on clinical history, imaging, functional measurements, airway examination, microbiological testing, and direct tissue inspection. These sources answer different questions: history supplies context, imaging shows chest findings, function and oxygenation address performance, while bronchoscopy, microbiology, and inspection examine airway, infectious, and tissue concerns. Their combination produces a broader evidence base for the decision.
A careful review identifies abnormalities that may affect preparation around transplantation, including edema, aspiration, infection, trauma, or impaired gas exchange. It also supports transparent decisions when organ quality is not uniformly ideal. By weighing these findings against recipient urgency and compatibility, clinicians may identify suitable lungs that could otherwise be declined, while keeping transplant outcomes central to the decision.