Outflow Graft
Outflow Graft - Related Videos
09:29
Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
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Cited by 31 •
2014
Marginal grafts, such as fatty livers, grafts from older donors, or livers retrieved after cardiac death (DCD) tolerate conventional, cold static storage only poorly. We developed a novel model of subnormothermic ex vivo liver perfusion for preservation, assessment, and repair of marginal liver grafts prior to transplantation.
08:12
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Cited by 43 •
2015
The severe organ shortage has resulted in increased use of marginal kidney grafts for transplantation. This has triggered interest in alternative storage methods, since marginal grafts especially tolerate cold storage poorly. The technique of normothermic ex vivo kidney perfusion (NEVKP) represents a novel preservation method for kidney grafts prior to transplantation.
07:37
Mouse Models for Graft Arteriosclerosis
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Cited by 17 •
2013
We describe protocols for our mouse graft arteriosclerois (GA) models which involve interposition of a mouse vessel segment into a recipient of the same inbred strain. By backcrossing additional genetic changes into the vessel donor, the model can assess the effect of specific genes on GA.
03:35
A Technique for Human Skin Grafting in a Mouse Model
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2025
This video demonstrates a method for grafting human skin onto an immunodeficient mouse with a suppressed neutrophil response. The method involves applying human split-thickness skin to the mouse's graft bed, sealing it, and covering it for recovery. Eventually, the human skin adheres to the mouse's skin, establishing vascularization and circulation, resulting in a successful skin xenograft.
05:47
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
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Cited by 14 •
2015
This report provides a detailed description of transplanting murine thymi from different aged donor mice under the kidney capsule of immunodeficient mouse recipients. The goal of this approach is to model T cell development and thymic selection events in vivo.
FAQs
Within an LVAD circuit, the outflow graft must preserve a continuous route from the pump outlet to the aorta. This allows blood drawn from the left ventricle to leave the mechanical pump and enter systemic circulation rather than relying solely on the weakened ventricle. Graft function therefore directly affects whether mechanical support produces effective forward flow.
Patency allows blood to pass through the intended pathway, while obstruction can limit the amount of support reaching the aorta. Kinking or malposition can also disrupt the graft’s course and reduce effective flow. Because these problems affect the connection between the device and systemic circulation, evaluating graft position is essential when assessing support performance.
These mechanical problems can reduce forward circulation even when the support device itself is intended to augment cardiac output. The resulting loss of effective flow may compromise the purpose of the system and create clinically important complications. For this reason, graft design, surgical attachment, and postoperative assessment are considered together rather than as isolated features.
Operative assessment focuses on how the graft is attached and whether its course provides an unobstructed connection to the receiving artery. Surgeons consider the graft’s position and patency as part of establishing effective support. These observations help identify technical problems during implantation and provide a baseline for later imaging or device-monitoring assessments.
Imaging, operative assessment, and device monitoring provide complementary information about graft function. Imaging can evaluate the graft’s position and patency, while device monitoring helps assess how the support system is performing. Together, these approaches can help clinicians investigate reduced support, identify possible mechanical problems, and guide subsequent treatment decisions.
The graft is particularly relevant when advanced heart failure has left native cardiac output inadequate and mechanical circulatory support is being used. In an LVAD, its connection to the aorta enables the pump to contribute to systemic circulation. Clinical and research attention therefore centers on maintaining reliable flow and preventing complications related to graft design or placement.