Tumor Histopathology
Tumor Histopathology - Related Videos
04:09
The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors
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Cited by 1 •
2026
This study details a standardized PCM-ESD protocol for resecting large rectal LSTs, aiming to enhance dissection speed and prevent transmural perforation via submucosal tunneling.
11:09
Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging
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Cited by 104 •
2010
Luciferase-modified human brain tumor xenografts can be established intracranially in athymic mice, with subsequent monitoring of tumor growth and response to therapy using bioluminescence imaging. In combination with survival analysis, bioluminescence monitoring is an essential research tool for pre-clinical testing of therapies being considered for treating brain tumors.
12:09
A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
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Cited by 14 •
2013
We describe a novel in vivo imaging technique that couples fluorescent chimeric mice with intracranial windows and high-resolution 2-photon microscopy. This imaging platform aids studies of dynamic changes in brain tissue and microvasculature, at a single-cell level, following pathological insults and is adaptable to assess intracranial drug delivery and distribution.
12:03
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
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Cited by 6 •
2016
This manuscript describes the development of an animal model that allows for the direct testing of the effects of tumor hypoxia on metastasis and the deciphering the mechanisms of its action. Although the experiments described here focus on Ewing sarcoma, a similar approach can be applied to other tumor types.
02:43
Tumor Implantation and Injection of a Tumor Vaccine in a Mouse Model
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2025
This video demonstrates a cell-based tumor vaccination assay. A mouse, intradermally injected with B16-F10 melanoma cells for tumor formation, is vaccinated with B16-F10 cells secreting Flt3L cytokine near the developed tumor. The secreted Flt3L from the vaccine promotes the maturation and proliferation of dendritic cells that then present tumor antigens to T cells in lymph nodes, triggering a targeted anti-tumor immune response.
FAQs
Several findings are interpreted together rather than in isolation. Cellular atypia signals abnormal cell appearance, while disorganized growth indicates loss of normal tissue architecture. Invasion shows that tumor cells extend into surrounding tissue; necrosis records areas of tissue breakdown, and mitotic activity reflects cell division visible in the specimen. Their combined pattern helps characterize tumor behavior.
The assessment weighs whether abnormal features occur as an integrated pattern. Cellular atypia, disorganized growth, invasion, necrosis, and mitotic activity are considered together because their combined presence provides more information than any single observation. This pattern-based review supports the benign-versus-malignant distinction and supplies a morphologic basis for classification, grading, and staging.
Immunohistochemistry adds marker-based evidence to the structural information seen on stained sections. By identifying lineage and tumor-specific markers, it can help characterize what type of tumor the cells represent when morphology alone is insufficient. This complementary analysis strengthens tumor classification and can inform treatment selection within a broader pathology assessment.
Correlating tissue morphology with molecular alterations connects what is visible under the microscope with underlying tumor biology. This relationship helps cancer research examine how structural patterns relate to molecular changes and supports precision oncology, in which tumor-specific information can contribute to selecting a more individualized treatment approach. The correlation extends histopathology beyond appearance alone.
After biopsy or surgical removal, the specimen is fixed, sectioned into thin samples, and stained for microscopic evaluation. The resulting sections are examined for cellular and architectural features, including atypia, disorganized growth, invasion, necrosis, and mitotic activity. This sequence converts the removed tissue into prepared material that can support systematic histopathologic assessment.
Pathologic findings serve several linked clinical purposes. They establish or support the diagnosis, place a tumor into a classification, and provide information used for grading and staging. Those results can then contribute to treatment selection and prognosis. Thus, the report translates microscopic observations into information relevant to patient management.
Beyond individual diagnosis, tumor histopathology provides a tissue-based foundation for cancer research and precision oncology. Researchers can relate observed morphology to molecular alterations, while clinicians use the resulting tumor-specific information alongside classification, grading, and staging. This integrated perspective supports investigation of cancer biology and helps connect microscopic findings with treatment selection and prognosis.