3-d Printing
3-d Printing - Related Videos
09:17
3D Printing of Biomolecular Models for Research and Pedagogy
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Cited by 29 •
2017
Physical models of biomolecules can facilitate an understanding of their structure-function for the researcher, aid in communication between researchers, and serve as an educational tool in pedagogical endeavors. Here, we provide detailed guidance for the 3D printing of accurate models of biomolecules using fused filament fabrication desktop 3D printers.
11:06
3D Printing of Preclinical X-ray Computed Tomographic Data Sets
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Cited by 16 •
2013
Using modern plastic extrusion and printing technologies, it is now possible to quickly and inexpensively produce physical models of X-ray CT data taken in a laboratory. The three -dimensional printing of tomographic data is a powerful visualization, research, and educational tool that may now be accessed by the preclinical imaging community.
06:44
3D Printing - Evaluating Particle Emissions of a 3D Printing Pen
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Cited by 20 •
2020
This protocol presents a method to analyze the emission of 3D printing pens. Particle concentration and particle size distribution of the released particle is measured. Released particles are further analyzed with transmission electron microscopy (TEM). Metal content in filaments is quantified by inductively coupled plasma mass spectrometry (ICP-MS).
09:38
Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
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Cited by 6 •
2017
Scalable engineered blood vessels would improve clinical applicability. Using easily sizable 3D-printed guides, rings of vascular smooth muscle were created and stacked into a tubular form, forming a vascular graft. Grafts can be sized to meet the range of human coronary artery dimensions by simply changing the 3D-printed guide size.
12:34
Methods for Measuring the Orientation and Rotation Rate of 3D-printed Particles in Turbulence
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Cited by 7 •
2016
We use 3D printing to fabricate anisotropic particles in the shapes of jacks, crosses, tetrads, and triads, whose alignments and rotations in turbulent fluid flow can be measured from multiple simultaneous video images.
FAQs
Programmed spatial coordinates determine where each deposited, cured, or solidified portion of material is placed. This enables researchers to adjust a structure’s overall geometry as well as its internal porosity and material composition. In neuroscience applications, that control supports the creation of tailored brain models, neural interfaces, and scaffolds designed for specific experimental or anatomical purposes.
These materials provide different ways to construct neural research objects and tissue-oriented models. Polymers can support manufactured structures, while hydrogels and biological inks are relevant when researchers aim to incorporate features associated with biological environments. Selecting among them affects the printed object’s composition and suitability for brain modeling, neural interfaces, or cell-based investigations.
Control over porosity and composition allows a scaffold to be designed with more than its external shape in mind. Researchers can investigate how different internal architectures and material arrangements represent aspects of neural tissue. This flexibility is valuable for studying neural development, injury, disease, and possible regenerative strategies rather than producing only a visually accurate structure.
When combined with bioprinting and cell-based methods, the process can extend beyond acellular models toward structures that reproduce selected aspects of brain architecture. Researchers can use this combination to examine neural tissue in contexts related to development, injury, and disease. It also provides a platform for investigating potential regenerative therapies while controlling the printed structure’s spatial organization.
A typical workflow begins with a digital design that specifies the intended structure and its spatial coordinates. The printer then deposits, cures, or solidifies the selected material according to that programmed design, building the object layer by layer. Depending on the goal, the resulting construct may serve as a brain model, teaching tool, surgical guide, neural interface, or tissue scaffold.
The approach is useful when a project requires a precisely shaped anatomical or experimental structure. Neuroscientists may apply it to create brain models and teaching tools, while clinical or translational work may use customized surgical guides and neural interfaces. Tissue-focused studies can use printed scaffolds to explore neural development, injury, disease, or regenerative therapy concepts.
Its outcomes range from physical representations of brain anatomy to customized devices and experimental scaffolds. A printed model can support anatomical teaching, whereas a surgical guide or neural interface can be tailored to a particular application. With biological inks and cell-based methods, researchers can also investigate constructs that reproduce selected features of brain architecture and neural tissue.