Neuroma Formation
Neuroma Formation - Related Videos
04:42
Generating a Rat Model of Tibial Neuroma Transposition
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2025
Source: Brakkee, E. M., et al. Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in Rats. J. Vis. Exp. (2023).This video demonstrates a procedure to generate a rat tibial neuroma transposition (TNT) model. After exposing the tibial nerve in the hind leg of an anesthetized rat, transect the nerve. Next, create a subcutaneous tunnel, thread the severed nerve through the tunnel, and suture it in place. In the absence of a target for reinnervation, disorganized axonal...
04:16
Stromal Vascular Fraction-Enriched Fat Grafting for the Management of Symptomatic Neuromas
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2025
Source: Zimmermann, S., et.al. Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata. J. Vis. Exp. (2017)This video demonstrates the surgical procedure for neurolysis and stromal vascular fraction (SVF)-enriched fat grafting in the management of symptomatic neuroma. Neurolysis removes adhesion tissue to restore nerve gliding, while SVF-enriched fat grafting is applied around the nerve to create a protective barrier, support nerve healing, and enhance...
07:00
Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
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2025
This protocol presents a reproducible rat model using sensory nerves to mimic human neuroma pain and assess surgical treatments, offering a valuable tool for translational neuroma research.
07:23
Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in Rats
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Cited by 2 •
2023
This protocol describes the tibial neuroma transposition model, which entails a lesion of the tibial nerve with subsequent transposition of the proximal nerve end toward a subcutaneous pretibial or lateral position. Behavioral testing of neuroma pain and plantar hyperalgesia is quantified using Von Frey monofilaments.
02:16
Solution Formation
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2020
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride. This selective solubility...
FAQs
After axonal transection, distal axon segments degenerate, while the proximal portion can produce new sprouts. These sprouts may continue growing without reaching an appropriate distal pathway. The mismatch between ongoing proximal regeneration and failed reconnection creates conditions for persistent, disorganized growth instead of restoration through a functional nerve route.
Regenerating axons require an appropriate route for organized reconnection. When the severed nerve ends cannot provide that pathway, proximal sprouts persist rather than being directed toward a functional target. This lack of guidance allows the sprouts to accumulate within surrounding tissue, linking failed reconnection to abnormal regeneration and neuroma development.
Schwann cells, fibroblasts, and extracellular matrix surround persistent axonal sprouts at the injured nerve site. Their presence contributes to the mixed cellular and supporting-tissue structure that characterizes the developing neuroma. Examining this interaction helps neuroscience researchers understand why regeneration becomes disorganized after injury and how the local tissue environment may influence nerve repair.
The abnormal regenerating nerve fibers associated with a neuroma may generate pain without an obvious stimulus or may respond painfully when the affected region is mechanically disturbed. These two patterns, spontaneous and mechanically evoked pain, connect the structural consequences of failed nerve regeneration with chronic neuropathic pain and provide important outcomes for symptom evaluation.
Neuroma formation provides a framework for studying the relationship between peripheral nerve injury, chronic neuropathic pain, and sensory dysfunction. It also connects basic research on axonal regeneration with efforts to improve nerve repair. Investigators can therefore use the process to examine both how abnormal regeneration develops and how it affects sensory experience over time.
Research informed by neuroma formation can focus on improving axonal guidance so regenerating fibers reach an appropriate pathway, while also limiting abnormal regeneration when reconnection is not achieved. These goals help link structural repair with functional outcomes. Evaluation of neuroma-related pain and sensory dysfunction can indicate whether an approach reduces harmful regeneration or improves recovery.