Pendulum Release

Pendulum release is a neurological assessment technique in which a relaxed limb is elevated, released, and observed as it swings under gravity, providing a simple measure of passive muscle tone. The movement reflects the interaction of limb inertia, gravity, joint mechanics, and stretch-reflex activity: reduced tone permits larger, freer oscillations, whereas increased tone dampens motion and limits the swing. In neuroscience, clinicians and researchers use pendulum release tests to characterize abnormalities such as spasticity, rigidity, or hypotonia and to compare neuromuscular function across time, conditions, or interventions. The method offers a practical, noninvasive complement to clinical examination and quantitative motion analysis.

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JoVE Core - Physics

Simple Pendulum

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2023

A simple pendulum consists of a small diameter ball suspended from a string, which has negligible mass but is strong enough to not stretch. In our daily life, pendulums have many uses, such as in clocks, on a swing set, and on a sinker on a fishing line. The period of a simple pendulum depends on two factors: its length and the acceleration due to gravity. The period is completely independent of any other factors, such as mass or maximum displacement. For small displacements, a pendulum is...

Torsional Pendulum

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2025

A torsional pendulum involves the oscillation of a rigid body in which the restoring force is provided by the torsion in the string from which the rigid body is suspended. Ideally, the string should be massless; practically, its mass is much smaller than the rigid body's mass and is neglected. As long as the rigid body's angular displacement is small, its oscillation can be modeled as a linear angular oscillation. The amplitude of the oscillation is an angle. The role of mass is played by the...

Physical Pendulum

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2023

When a rigid body is hanging freely from a fixed pivot point and is displaced, it oscillates similar to a simple pendulum and is known as a physical pendulum. The period and angular frequency of a physical pendulum are obtained by using the small-angle approximation and drawing parallels with a spring-mass system. The small-angle approximation (sinθ=θ) is valid up to about 14°. When dealing with complicated systems, the mass moment of inertia is an important parameter, as it describes the mass...

Energy-releasing Steps of Glycolysis

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2019

Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase. The first energy-releasing step—the 6th step of glycolysis —consists of two...

Modified-Release Drug Delivery Systems: Drug Release Characteristics

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2026

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

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