Stress-induced Relapse
Stress-induced Relapse - Related Videos
08:05
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
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Cited by 3 •
2022
A procedure that demonstrates a robust acute food deprivation-induced relapse to heroin seeking after punishment-imposed abstinence is described. A punishment-imposed abstinence model was successfully implemented using the seek and take chain schedule for heroin self-administration. Heroin-seeking tests are then performed following 24 h of food-deprivation stress.
09:39
The Trier Social Stress Test Protocol for Inducing Psychological Stress
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Cited by 251 •
2011
This article describes a protocol for inducing psychological stress in participants, which enables researchers to measure psychological, physiological and neuroendocrine responses to stress within single participants or between groups.
08:31
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
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2025
The protocol aims to describe a mouse model for generating relapses of acute lymphoblastic leukemia, based on the dynamics of the response to induction chemotherapy.
02:12
Inducing Depression-like Behavior in a Mouse via Immobilization Stress
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2025
This video demonstrates the method of inducing chronic stress in a mouse through repeated immobilization, leading to corticosterone release and reduced glutamate receptor activity in neurons, which results in depression-like behavior.
26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
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Cited by 27 •
2007
This video demonstrates the induction and clinical scoring of an animal model of multiple sclerosis: chronic-relapsing experimental autoimmune encephalomyelitis in DA rats. The disease, induced by immunizing rats with an emulsion containing whole rat spinal cord and complete Freund's adjuvant, presents clinical signs resembling the human disease.
FAQs
Stress activates the hypothalamic-pituitary-adrenal axis, a neuroendocrine system that coordinates the body’s response to challenging conditions. This activation is linked with corticotropin-releasing factor signaling, which can influence brain systems involved in craving and addiction-related behavior. Studying this pathway helps researchers identify stress-regulation processes that may be relevant to relapse vulnerability and treatment development.
Corticotropin-releasing factor signaling provides an important connection between stress responses and neural changes associated with drug seeking. In the context of stress-induced relapse, it can alter amygdala activity and contribute to stronger drug-associated memories. These effects help explain why stressful experiences may reactivate addiction-related responses after abstinence, even when the individual has previously received treatment.
Stress can influence relapse through two complementary effects: it may strengthen memories linked to drug use while weakening control over behavior. Amygdala activity is relevant to this interaction because the amygdala participates in stress-related processing and drug-associated responses. Together, these changes can increase craving and make addiction-related behavior more likely when stressful experiences occur.
Experimental models use stress exposure and cue-induced reinstatement paradigms to examine how relapse-related behaviors are reactivated after abstinence. These approaches allow researchers to investigate the relationship among stressful experiences, drug-associated cues, craving, and behavioral control. Their value lies in providing structured ways to study relapse vulnerability and evaluate mechanisms that may guide future therapeutic strategies.
These models can help identify how stress regulation, amygdala activity, corticotropin-releasing factor signaling, and drug-associated memories contribute to relapse vulnerability. They also support comparisons between the effects of stress exposure and cue-related triggers on addiction-related behavior. The resulting information can clarify which processes deserve attention when researchers investigate recovery outcomes and potential interventions.
Stress-induced relapse connects psychological and physiological stress responses with neural mechanisms that influence craving, memory, and behavioral control. This makes it an important neuroscience framework for understanding why abstinence does not eliminate relapse vulnerability. Research in this area supports development of therapies aimed at regulating stress, reducing vulnerability to relapse, and improving recovery outcomes after treatment.