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A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
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JoVE Journal Behavior
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

DOI:
10.3791/63657-v

•

08:05 min

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March 23, 2022

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, ,
1Department of Psychology, Center for Studies in Behavioral Neurobiology,Concordia University

Chapters

  • 00:04Introduction
  • 00:43Behavioral Procedure
  • 06:39Results: Acute Food Deprivation-Induced Relapse to Heroin Seeking Abstinence in the Rats
  • 07:27Conclusion

Summary

Automatic Translation

Automatic Translation

A procedure that demonstrates a robust acute food deprivation-induced relapse to heroin seeking after punishment-imposed abstinence is described. A punishment-imposed abstinence model was successfully implemented using the seek and take chain schedule for heroin self-administration. Heroin-seeking tests are then performed following 24 h of food-deprivation stress.

Tags

Keywords: Stress-induced RelapseHeroin SeekingPunishment-imposed AbstinenceOperant Conditioning ChambersSelf-administrationSeek-take ChainFixed Ratio OneHeroin InfusionIntertrial IntervalEcological Validity

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