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JoVE Journal Behavior
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
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A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Article DOI: 10.3791/63657-v • 08:05 min • March 23rd, 2022
March 23rd, 2022 •
1, 1, 1
1Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University

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Summary
Automatic Translation

A procedure that demonstrates a robust acute food deprivation-induced relapse to heroin seeking after punishment-imposed abstinence is described. A punishment-imposed abstinence model was successfully implemented using the seek and take chain schedule for heroin self-administration. Heroin-seeking tests are then performed following 24 h of food-deprivation stress.

Tags

Stress-induced Relapse Heroin Seeking Punishment-imposed Abstinence Neuronal Mechanism Voluntary Abstinence Operant Conditioning Chambers Habituation Self-administration Of Heroin Take Lever Fixed Ratio One Training Session Cue Light Timeout Period Heroin Infusion
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