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Journal / Cancer Research / 使用急性淋巴细胞白血病患者来源的异种移植小鼠模型评估嵌合抗原受体T细胞相关毒性…
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JoVE Journal Cancer Research
使用急性淋巴细胞白血病患者来源的异种移植小鼠模型评估嵌合抗原受体T细胞相关毒性
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使用急性淋巴细胞白血病患者来源的异种移植小鼠模型评估嵌合抗原受体T细胞相关毒性

Article DOI: 10.3791/64535-v • 06:08 min • February 10th, 2023
February 10th, 2023 •
1,2,3,4,5, 1,2, 1,2, 6, 6, 1,2, 1,2, 6, 1,2,6
1T Cell Engineering Laboratory, Mayo Clinic, Rochester, 2Division of Hematology, Mayo Clinic, Rochester, 3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 4Department of Molecular Medicine, Mayo Clinic, Rochester, 5Regenerative Sciences PhD Program, Mayo Clinic, Rochester, 6Department of Immunology, Mayo Clinic, Rochester

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在这里，我们描述了一种方案，其中使用急性淋巴细胞白血病患者来源的异种移植模型作为评估和监测CD19靶向嵌合抗原受体T细胞相关毒性的策略。

Tags

癌症研究，第 192 期，CART 细胞，CART 细胞相关毒性，患者来源的异种移植 （PDX） 模型，癌症治疗， 体内 临床前模型
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