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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Article DOI: 10.3791/64544-v • 13:41 min • January 13th, 2023
January 13th, 2023 •
1,2, 3, 3, 2, 3,4, 5, 5, 1,2, 6, 6, 7, 3,8, 3,9, 1,3,4,10, 1,2,10
1Institute of Medical Science, University of Toronto, 2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 3The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, 4Institute of Biomedical Engineering, University of Toronto, 5Leslie Dan Faculty of Pharmacy, University of Toronto, 6Departments of Radiology and Clinical Neurosciences, University of Calgary, 7Department of Radiation Oncology, University of Toronto, 8Department of Medical Imaging, University of Toronto, 9Department of Pediatric Surgery, University of Toronto, 10Department of Surgery, University of Toronto

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요약
Automatic Translation

Presented here is a protocol to use controlled hyperthermia, generated by magnetic resonance-guided high intensity focused ultrasound, to trigger drug release from temperature-sensitive liposomes in a rhabdomyosarcoma mouse model.

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia Preclinical Testing Tumor Targeted Hyperthermia Thermo Sensitive Drugs Survival Improvement Systemic Toxicity Reduction Sarcoma Treatment Chemotherapy Release Confinement Localized Hypothermia Immune System Activation Cancer Targeting Standard Chemotherapy MRI Physicist HIFU Physicist Master's Graduate In Applied Science Mouse Shaving Cell Suspension Injection
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