Chromatid Movement by Microtubule Forces

Chromatid movement during anaphase depends on microtubule forces at the spindle. Kinetochore microtubules grow from the spindle poles, and their plus ends attach to kinetochores on sister chromatids. The kinetochore protein complex Ndc80 makes low-affinity links with the microtubule plus end.

Chromosome segregation takes place during anaphase: when the sister-chromatids separate and the individual chromatids move toward the opposite poles of the cell.

Anaphase progression constitutes two independent but overlapping processes: Anaphase A and Anaphase B.

During Anaphase A, in the absence of sister-chromatid cohesion, two ...