Kinetochore-Microtubule Binding in Mitosis

Kinetochore-microtubule binding helps chromosomes line up and separate during mitosis. After the nuclear envelope breaks down, condensed chromosomes are exposed to the bipolar microtubules of the mitotic spindle. The kinetochore is a large, disc-shaped protein complex at the centromere region of each sister chromatid, and it...

During mitosis, following the assembly of a bipolar microtubule array, the kinetochore microtubules attach to the sister-chromatids.

Microtubules attach to each chromatid via the kinetochore located at the centromere. Multiple microtubules from the same spindle pole can bind to a single kinetochore to form the kinetochore fiber.

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