How the Mitotic Spindle Forms

The mitotic spindle forms through centrosome-mediated, chromatin-mediated, and microtubule-mediated pathways. These pathways often work at the same time. Together, they build a strong spindle apparatus for cell division.

In most cells, centrosomes are the main sites where microtubules begin to gr...

During eukaryotic cell division, microtubules assemble around the duplicated chromosomes in a bipolar array, forming the spindle apparatus. Spindle assembly is aided by multiple collaborating mechanisms.

Spindle assembly begins after two centrosomes are positioned at opposite ends of the cell. In animal cells, spindle poles are located at...