Chronic Inflammation
Chronic Inflammation - Related Videos
07:10
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
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Cited by 25 •
2013
We describe a non-invasive imaging method for distinguishing inflammatory stages. Systemic delivery of luminol reveals areas of acute inflammation dependent upon MPO activity in neutrophils. In contrast, injection of lucigenin allows for visualization of chronic inflammation dependent upon Phox activity in macrophages.
09:52
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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Cited by 15 •
2014
Animal models have proven to be invaluable tools in defining host and pathogen specific mechanisms that contribute to the development of chronic inflammation. Here we describe a mouse model of oral infection with the human pathogen Porphyromonas gingivalis and detail methodologies to assess the progression of inflammation at local and systemic sites.
01:12
Chronic Inflammation: Introduction
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2026
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:38
Inflammation
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2019
Overview In response to tissue injury and infection, mast cells initiate inflammation. Mast cells release chemicals that increase the permeability of adjacent blood capillaries and attract additional immune cells to the wound or site of infection. Neutrophils are phagocytic leukocytes that exit the bloodstream and engulf invading microbes. Blood clotting platelets seal the wound and fibers create a scaffold for wound healing. Macrophages engulf aging neutrophils to end the acute inflammatory...
07:46
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Cited by 15 •
2017
This protocol allows a researcher to isolate and characterize tissue-resident macrophages in various hallmark inflamed tissues extracted from diet-induced models of metabolic disorders.
FAQs
Persistent activation of immune cells maintains the release and activity of inflammatory signaling molecules even after an initiating threat has been contained, or while tissue injury and other stimuli continue. This sustained signaling keeps immune and tissue-repair pathways engaged. Over time, the response can extend beyond protection, altering nearby tissue and interfering with normal biological function.
Tissue repair is intended to restore damaged structures, but prolonged engagement of repair pathways can contribute to continuing tissue remodeling. In chronic inflammation, repeated immune activity and repair signals may gradually change the surrounding tissue rather than resolve the original problem. These structural alterations can impair normal function and influence how disease progresses.
Chronic inflammation may persist when tissue injury, infection, or another inflammatory stimulus continues over time. It can also remain after an initiating threat has been contained, indicating that the immune response has not fully returned to a resting state. Identifying the continuing or unresolved stimulus helps researchers relate inflammatory activity to tissue changes and disease progression.
Sustained immune activity can influence several disease contexts by changing tissue behavior and normal function. In autoimmune disease, it helps explain the consequences of persistent immune activity; in metabolic disorders and cancer, it provides a framework for studying how inflammatory signaling and tissue remodeling may shape disease progression. The specific relationship depends on the biological setting being investigated.
Studies commonly focus on the activity of immune cells, inflammatory signaling molecules, and tissue-repair pathways. Researchers also examine how these processes alter surrounding tissue and affect normal function. This combination of cellular, molecular, and tissue-level observations helps connect persistent inflammation with remodeling and disease progression rather than viewing immune activation in isolation.
Biomarkers help researchers identify and characterize inflammatory activity in biological investigations. In this context, they can support efforts to connect immune activation, signaling, tissue remodeling, and disease progression. Identifying relevant biomarkers also provides a basis for evaluating whether an anti-inflammatory treatment changes the biological processes associated with persistent inflammation.
Treatment evaluation is particularly relevant when persistent immune activity is linked to ongoing tissue alteration or impaired function. Researchers can use studies of chronic inflammation to examine whether an intervention affects inflammatory signaling, immune-cell activation, or tissue-repair pathways. These findings may clarify how treatment influences remodeling and progression in autoimmune disease, metabolic disorders, or cancer.
Such studies can clarify how prolonged immune activity interacts with tissue-repair processes and gradually changes surrounding tissue. They can also identify biomarkers, support evaluation of anti-inflammatory treatments, and explain connections between inflammation and disease progression. Together, these outcomes help link basic biology with the investigation of autoimmune disease, metabolic disorders, and cancer.