Tooth Enamel Demineralization

Tooth enamel demineralization is the chemical loss of mineral ions, primarily calcium and phosphate, from enamel, the hard outer layer of a tooth. It matters because repeated mineral loss weakens enamel and can initiate dental caries. Acids produced when oral bacteria metabolize fermentable carbohydrates, or introduced through acidic foods and drinks, lower plaque pH and drive hydroxyapatite dissolution; saliva can buffer these acids and support remineralization when conditions recover. Studying this acid-base and solubility process helps explain how fluoride, saliva, dietary choices, and preventive treatments influence enamel stability, guiding strategies to prevent caries and informing dental materials and oral health research.

Tooth Enamel Demineralization - Related Videos

Research

JoVE Journal - Bioengineering

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

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Cited by 32 •

2014

In this article, we describe a protocol for fabricating an amelogenin-chitosan hydrogel for superficial enamel reconstruction. Organized in situ growth of apatite crystals in the hydrogel formed a dense enamel-restoration interface, which will improve the effectiveness and durability of restorations.

Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis

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Cited by 30 •

2018

Stable carbon and oxygen isotope analysis of human and animal tooth enamel carbonate has been used as a proxy for individual diet and environmental reconstruction. Here, we provide a detailed description and visual documentation of bulk and sequential tooth enamel sampling as well as pretreatment of archaeological and paleontological samples.

Analyzing Tooth Germ and Trigeminal Ganglia Interactions Using a Microfluidic Co-culture System

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2025

This video demonstrates the utilization of a microfluidic device to study the interactions between tooth germ pulp and trigeminal ganglia. It showcases the placement of tissues inside the microfluidic device and provides a detailed visualization of trigeminal neurite growth toward the tooth germ through the device's microgrooves. Additionally, it highlights the role of tooth-derived molecular factors in promoting or inhibiting neurite extension into the tooth germ pulp, which is crucial for...

Education

JoVE Core - Anatomy and Physiology

Tooth Anatomy

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2024

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth. The Crown, Neck, and Root The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

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Cited by 10 •

2015

Co-cultures represent a valuable method to study the interactions between nerves and target tissues and organs. Microfluidic systems allow co-culturing ganglia and whole developing organs or tissues in different culture media, thus representing a valuable tool for the in vitro study of the crosstalk between neurons and their targets.

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