Organ Pathology
Organ Pathology - Related Videos
08:59
Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps
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Cited by 3 •
2018
Here, we provide a workflow that allows the identification of healthy and pathological cells based on their 3-dimensional shape. We describe the process of using 2D projection outlines based on the 3D surfaces to train a Self-Organizing Map that will provide objective clustering of the investigated cell populations.
08:29
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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Cited by 7 •
2016
Organized brain cutting procedures are necessary to correlate specific neuropsychiatric phenomena with definitive neuropathologic diagnoses. Brain cuttings are performed differently based on various clinico-academic contingencies. This protocol describes a symmetric bihemispheric brain cutting procedure to investigate hemispheric differences in human brain pathologies and to maximize current and future biomolecular/neuroimaging techniques.
01:24
Evaluating the Effect of a Synbiotic Formulation on Alzheimer’s Disease Pathology in Drosophila
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2025
Take a transgenic Drosophila.The brain of the Drosophila expresses the human amyloid peptide protein or APP and a cleaving enzyme.The enzyme cleaves APP, enabling the formation of beta-amyloid plaque, which leads toAlzheimer's disease or AD pathology in Drosophila.Feed the Drosophila AD model a diet containing a synbiotic formulation.The formulation contains a combination of three bioactive probiotic bacteria and a prebiotic.Inside the fly's gut, the prebiotic supports the growth and survival...
10:38
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
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Cited by 10 •
2020
The current study highlights a standardized approach to the macroscopic assessment of distal pancreatectomy specimens for pancreatic ductal adenocarcinoma, with special emphasis on the measurement of pancreatic dimensions and those of other organs, inking of margins, measurement of tumor size and proximity to margins, lymph node sampling and block selection.
03:02
Organic Compounds
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2020
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
FAQs
The connection comes from comparing structural abnormalities with evidence of impaired organ function. Gross examination shows changes at the organ level, while microscopic examination evaluates tissue sections and disease-associated patterns. Pathologists then interpret these findings alongside laboratory results, imaging, medical history, and clinical measures of organ function, helping explain how observed abnormalities relate to patient signs and outcomes.
Using both levels of examination allows investigators to recognize different manifestations of disease rather than relying on a single observation. Tissue assessment may identify patterns associated with injury, inflammation, degeneration, infection, vascular change, or neoplasia. These findings provide a structured basis for interpreting abnormal specimens and relating their appearance to the suspected disease process.
Recognizing recurring patterns helps organize tissue abnormalities into clinically meaningful categories. Injury, inflammation, degeneration, infection, vascular change, and neoplasia can each provide different evidence about what is happening in an organ. Their identification becomes more informative when correlated with the patient's history and other clinical data, supporting a coherent interpretation rather than an isolated microscopic description.
Interpretation requires more than the specimen alone. The tissue findings should be considered with the patient's medical history, imaging results, laboratory data, and available measures of organ function. Examination commonly includes gross and microscopic assessment, with tissue sections and stains used to identify relevant abnormalities. This integrated approach helps place specimen findings in their clinical context.
Findings from organ pathology can establish a diagnosis by linking observed structural changes with clinical evidence. The extent and nature of abnormalities may also help assess how severely an organ is affected when interpreted alongside organ-function results and other patient data. This information supports clinical decisions about the significance of a biopsy or surgical specimen.
Clinical interpretations can guide treatment decisions and help assess prognosis by clarifying the disease-related changes present in an organ. Beyond individual patient care, organ pathology helps researchers investigate disease mechanisms and evaluate emerging therapies. Its value therefore extends from interpreting clinical specimens to connecting tissue-level observations with expected outcomes and therapeutic assessment.