Aortic Sinus
Aortic Sinus - Related Videos
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Cited by 51 •
2013
We describe procedures to quantify and characterize atherosclerotic lesions in mouse models using precision sectioning of the aortic sinus and ascending aorta combined with histochemical and immunohistochemical analysis.
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
08:46
Nose, Sinuses, Oral Cavity and Pharynx Exam
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2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA This video provides an overview of sinus, nose, and throat examinations. The demonstration begins with a brief overview of the anatomy of the region. The upper third of the nose is bony, and the bottom two-thirds are cartilaginous. Air entering the nares passes through the nasal vestibules and into the narrow passageway between the nasal septum...
07:34
Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
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2025
This study presents a protocol for establishing a reproducible, minimally invasive rat model of superior sagittal sinus thrombosis induced by ferric chloride, utilizing a silk-suture method in combination with laser speckle contrast imaging and high-resolution ultrasound for evaluation.
09:12
Aortic Ring Assay
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Cited by 42 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
FAQs
During systole, the sinus-shaped spaces organize local vortices that help separate the aortic valve leaflets as blood exits the left ventricle. During diastole, related flow behavior supports leaflet closure. This coupling between geometry and motion is important when engineers analyze efficient valve operation and assess whether a design reproduces the dynamic behavior of the aortic root.
Flow within the sinuses helps direct blood toward the coronary arteries while the valve cycles between opening and closing. That makes coronary access a design consideration, not merely a consequence of the valve outlet. Engineering analyses therefore examine whether altered sinus dimensions or flow patterns could change the intended routing of blood near the aortic root.
The dimensions of the sinuses and the flow patterns they produce are central variables for engineering analysis. They influence how efficiently blood moves around the valve, how the leaflets separate and close, and how flow is directed toward the coronary arteries. Comparing these relationships helps identify designs that may reduce abnormal stresses while preserving intended cardiovascular function.
In computational fluid dynamics, engineers can use aortic sinus geometry to study the local flow patterns associated with valve motion and coronary-directed flow. The analysis connects physical shape with outcomes such as leaflet separation, closure, and abnormal stress. This makes the sinus a useful geometric feature to include when evaluating cardiovascular flow rather than treating the valve as an isolated component.
Biomimetic valve designs can draw on the sinus’s natural relationship between shape and flow. Reproducing relevant geometric features may help a prosthetic valve support leaflet opening during systole, closure during diastole, and appropriate flow toward the coronary arteries. The engineering goal is not simply to copy anatomy, but to preserve flow functions that contribute to efficient valve performance.
During cardiovascular device development, researchers can compare sinus dimensions and flow behavior with expected valve performance. These comparisons may reveal designs associated with abnormal stresses or less effective flow routing, guiding refinements to prosthetic valves and other devices. The same engineering perspective is relevant to aortic disease, where safer designs require attention to both anatomy and local cardiovascular flow.