Autologous Pericardium Valve
Autologous Pericardium Valve - Related Videos
05:31
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
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Cited by 4 •
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This study demonstrates the feasibility and safety of developing an autologous pulmonary valve for implantation at the native pulmonary valve position by using a self-expandable Nitinol stent in an adult sheep model. This is a step toward developing transcatheter pulmonary valve replacement for patients with right ventricular outflow tract dysfunction.
07:15
An Intact Pericardium Ischemic Rodent Model
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This protocol outlines the steps for inducing myocardial infarction in mice while preserving the pericardium and its contents.
10:44
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
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Clinically relevant animal models of intracerebral hemorrhage (ICH) are needed to extend our knowledge of hemorrhagic stroke and to examine novel therapeutic strategies. In this study, we describe and evaluate two ICH models that implement unilateral injections of either autologous whole blood or bacterial collagenase into the basal ganglia (corpus striatum) of mice.
11:12
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
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Cited by 5 •
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There has been renewed interest in developing polymer valves. Here, the objectives are to demonstrate the feasibility of modifying a commercial pulse duplicator to accommodate tri-leaflet geometries and to define a protocol to present polymer valve hydrodynamic data in comparison to native and prosthetic valve data collected under near-identical conditions.
08:55
Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification
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Cited by 17 •
2017
This protocol describes the isolation, culture, and calcification of rat-derived valve interstitial cells, a highly physiological in vitro model of calcific aortic valve disease (CAVD). Exploitation of this rat model facilitates CAVD research in exploring the cell and molecular mechanisms that underlie this complex pathological process.
FAQs
Its leaflets respond to changing pressure on either side of the valve. When pressure favors forward flow, the leaflets open; when pressure reverses, they come together to limit backward movement. This pressure-responsive action is central to maintaining one-way circulation, linking the reconstructed valve’s physical behavior directly to normal cardiac flow patterns.
Patient-derived tissue allows the reconstruction to be tailored to the individual cardiac anatomy rather than relying entirely on a manufactured component. This individualized approach is relevant when surgeons want to avoid introducing foreign prosthetic materials, while also supporting research into how biological tissue can function as a reconstructed valve structure.
The main distinction is the source and construction of the valve material. An autologous approach uses tissue obtained from the same patient, whereas a manufactured prosthetic valve is produced from external materials. This difference matters clinically because the surgical team may choose patient-derived tissue when avoiding foreign prosthetic materials is an important consideration.
Shaping the harvested pericardial tissue creates the leaflets, while securing them within the native valve position establishes their working attachment. These construction steps determine whether the leaflets can respond to pressure changes by opening and closing in the intended location. Their relationship to the native valve position is therefore essential for regulating one-way blood flow.
The procedure begins with harvesting pericardial tissue from the patient. Surgeons then shape that tissue into valve leaflets and secure the reconstructed structure within the native valve position. The completed arrangement is intended to preserve pressure-dependent opening and closing, allowing the reconstructed valve to participate in controlled, one-way cardiac blood flow.
This approach may be considered when valve repair or replacement is needed and the surgical team seeks to avoid foreign prosthetic materials. It provides an option for individualized cardiac reconstruction using tissue from the patient. The choice is therefore connected both to the required valve intervention and to the material considerations surrounding manufactured prostheses.
The intended functional outcome is controlled one-way blood flow through the native valve position. As cardiac pressures change, the reconstructed leaflets should open to permit forward movement and close when pressure reverses. This behavior provides the key physiological basis for using the tissue in cardiac valve reconstruction.
Autologous pericardium valves connect surgical reconstruction with biomaterial research because they use patient-derived tissue as a functional valve material. Their study can examine how biological tissue is shaped, attached, and integrated into an individualized cardiac repair or replacement strategy. The approach therefore informs both cardiovascular surgery and research on alternatives to manufactured prosthetic valves.