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JoVE Journal
Developmental Biology

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Isolation and Characterization of Primary Rat Valve Interstitial Cells
 

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

Article doi: 10.3791/56126
November 20th, 2017 Usage Statistics

Summary November 20th, 2017

This protocol describes the isolation, culture, and calcification of rat-derived valve interstitial cells, a highly physiological in vitro model of calcific aortic valve disease (CAVD). Exploitation of this rat model facilitates CAVD research in exploring the cell and molecular mechanisms that underlie this complex pathological process.

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