Fibrous Plaques
Fibrous Plaques - Related Videos
02:21
Globular and Fibrous Proteins
0 Views •
2020
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities. Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
13:45
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
0 Views •
Cited by 5 •
2022
We have developed a mechano-imaging pipeline to study the heterogeneous structural and mechanical atherosclerotic plaque properties. This pipeline enables correlation of the local predominant angle and dispersion of collagen fiber orientation, the rupture behavior, and the strain fingerprints of the fibrous plaque tissue.
13:00
Plaque Assay: A Method to Determine Viral Titer as Plaque Forming Units (PFU)
0 Views •
2023
Source: Tilde Andersson1, Rolf Lood1 1 Department of Clinical Sciences Lund, Division of Infection Medicine, Biomedical Center, Lund University, 221 00 Lund, Sweden Viruses that infect prokaryotic organisms, called bacteriophages or simply phages, were identified in the early 20th century by Twort (1) and d'Hérelle (2) independently. Phages have since been widely recognized for their therapeutic value (3) and their influence on human (4), as well as global, ecosystems (5). Current concerns have...
10:53
Plaque Assay for Murine Norovirus
0 Views •
Cited by 99 •
2012
Here we describe a method to quantify infectious particles of murine norovirus (MNV), which is the only norovirus that efficiently replicates in cell culture. The plaque assay takes advantage of MNV’s tropism for murine macrophages and can be adapted for use with biological or environmental samples containing MNV.
00:55
Fibrous Proteins
0 Views •
2023
Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
FAQs
Endothelial dysfunction allows lipoproteins to remain within the arterial wall, where they contribute to inflammation. This inflammatory environment recruits and alters local vascular cells, creating conditions that promote smooth muscle cell movement into the intima. The resulting cellular response begins the structural remodeling associated with plaque formation and progression.
After migrating into the intima, smooth muscle cells produce collagen that contributes to a fibrous cap over the lipid-rich portion of a lesion. This cap is a key structural feature because its integrity influences whether the plaque remains contained or becomes vulnerable to disruption, linking microscopic composition with clinical risk.
A plaque may enlarge within the arterial wall and progressively reduce the space available for blood flow, producing chronic narrowing. In a different course, the fibrous cap can become unstable and rupture. Rupture permits thrombosis, or clot formation, which can abruptly obstruct the vessel and produce an acute vascular event.
Risk assessment considers both the extent of arterial narrowing and the structural stability of the lesion. A plaque that substantially reduces the vessel lumen indicates progressive obstruction, while an unstable cap signals potential rupture and thrombosis. Evaluating these features helps connect plaque pathology with the likelihood of heart attack or stroke.
Their structure and severity can be assessed through diagnostic imaging and pathological analysis. These approaches provide information about the lesion’s extent, composition, and relationship to the arterial wall. Such findings help characterize disease progression, support cardiovascular risk assessment, and clarify whether plaque features may contribute to obstruction or acute complications.
Structural assessment shows whether disease is associated mainly with progressive narrowing or with features that could permit cap rupture and thrombosis. That distinction is clinically relevant because both mechanisms can impair blood flow, but sudden thrombotic obstruction creates an acute hazard. Plaque characterization therefore supports strategies aimed at preventing heart attack and stroke.