Growth Mixture Modeling

Growth Mixture Modeling (GMM) is a statistical method for identifying unobserved subgroups within a population that follow distinct patterns of change over time. In longitudinal medical data, GMM combines growth-curve modeling with latent-class analysis: it estimates average trajectories for each subgroup while quantifying individual variation and assigning each participant a probability of belonging to each class. This framework can reveal clinically meaningful patterns of disease progression, symptom development, treatment response, or recovery that may be obscured by population-wide averages, helping researchers formulate hypotheses about prognosis, stratify participants for analysis, and evaluate whether interventions have different effects across latent groups.

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Research

JoVE EoE - Bacterial Growth and Techniques

Application of a Bacterial Mixture as a Biofertilizer to Enhance Plant Growth

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2025

Take an inoculum mixture of phosphate-solubilizing bacteria or PSB and purple non-sulfur bacteria or PNSB.Spray the mixture onto the soil mixed with fertilizer and cow dung manure.Sow the seed and cover it with the soil.Allow the plant to grow.The bacteria localize near the root in a zone called the rhizosphere.PSB converts insoluble soil phosphates into soluble forms.Meanwhile, PNSB fixes nitrogen by converting atmospheric nitrogen gas into ammonia.The plant absorbs the soluble phosphates and...

Education

JoVE Core - Chemistry

Mixtures of Acids

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2020

The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants. A Mixture of a Strong Acid and a Weak Acid In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...

Education

JoVE Core - Analytical Chemistry
Free Sample

Mixtures of Acids

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2025

The pH of a solution containing an acid can be determined using its acid dissociation constant and initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending on the relative strength of the acids and their dissociation constants. In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...

Separation of Mixtures via Precipitation

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2023

Source: Laboratory of Dr. Ana J. García-Sáez — University of Tübingen Most samples of interest are mixtures of many different components. Sample preparation, a key step in the analytical process, removes interferences that may affect the analysis. As such, developing separation techniques is an important endeavor not just in academia, but also in industry. One way to separate mixtures is to use their solubility properties. In this short paper, we will deal with aqueous solutions. The...

Ideal Solutions or Mixtures

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2026

From a molecular perspective, an ideal solution is one in which the intermolecular interactions between unlike molecules are, on average, the same as those between like molecules. This is the case for ideal gas mixtures, where the molecules are far apart and do not interact with each other. However, for condensed phases like liquids or solids, the molecules are close together and interact with each other. In an ideal solution, the molecules of different species are so similar to each other that...

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