Perfusion Pressure
Perfusion Pressure - Related Videos
09:38
Procedure for Decellularization of Rat Livers in an Oscillating-pressure Perfusion Device
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Cited by 18 •
2015
The presented techniques for liver harvesting, cannulation and perfusion using our proprietary device enable sophisticated perfusion set-ups to improve decellularization and recellularization experiments in rat livers.
07:26
Synthesis and Microdiffraction at Extreme Pressures and Temperatures
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Cited by 5 •
2013
The laser heated diamond anvil cell combined with synchrotron micro-diffraction techniques allows researchers to explore the nature and properties of new phases of matter at extreme pressure and temperature (PT) conditions. Heterogeneous samples can be characterized in situ under high pressure by 2D mapping and combined powder, single-crystal and multigrain diffraction approaches.
04:44
Antegrade Perfusion Model: An Ex Vivo Technique to Perfuse Isolated Mouse Heart
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2025
This video describes an antegrade perfusion technique of an isolated mouse heart during which a perfusate is injected through the left ventricle, and eventually, it perfuses the entire myocardium. This method can be used to isolate cardiomyocytes from murine models and generate decellularized hearts for further downstream applications.
09:00
Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
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Cited by 6 •
2016
The heterogeneous intra-tumoral accumulation of liposomes has been linked to an abnormal tumor microenvironment. Herein methods are presented to measure tumor microcirculation by perfusion imaging and elevated interstitial fluid pressure (IFP) using an image-guided robotic system. Measurements are compared to the intra-tumoral accumulation of liposomes, determined using volumetric micro-CT imaging.
08:53
Whole Animal Perfusion Fixation for Rodents
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Cited by 531 •
2012
Here we describe a low-cost, rapid, controlled and uniform fixation procedure using 4% paraformaldehyde perfused via the vascular system: through the heart of the rat to obtain the best possible preservation of the brain.
FAQs
Perfusion pressure depends on both sides of the vascular bed, not on arterial pressure alone. A reduction in upstream arterial pressure lowers the driving gradient, while increased venous or surrounding pressure can also oppose inflow. This relationship explains why tissue circulation may become inadequate even when arterial pressure appears relatively preserved.
In the brain, cerebral perfusion pressure changes whenever mean arterial pressure or intracranial pressure changes. A fall in the former or a rise in the latter narrows the gradient, potentially reducing oxygen delivery. Clinicians therefore interpret these pressures together rather than treating either measurement as a complete indicator of cerebral circulation.
The relevant downstream value may be venous pressure or pressure surrounding the organ, depending on the tissue being assessed. When that opposing pressure increases, the effective gradient across the vascular bed decreases. Considering this component helps explain impaired circulation and potential metabolic waste accumulation without assuming that the arterial measurement alone determines tissue perfusion.
During shock, clinicians use perfusion pressure to judge whether circulation is sufficient to support oxygen and nutrient delivery. Fluid therapy may help address inadequate circulating pressure, while vasopressor use can support arterial pressure when clinically appropriate. Monitoring the resulting gradient helps guide treatment decisions intended to reduce the risk of ischemic tissue injury.
Trauma and anesthesia are settings in which clinicians may need to assess whether organs are receiving adequate circulation. Perfusion pressure monitoring provides a pressure-based measure that can support decisions about fluid therapy, vasopressors, and other treatment priorities. Its value lies in connecting hemodynamic changes with the risk of inadequate tissue oxygenation and ischemic injury.
Changes in perfusion pressure can signal that the pressure gradient supporting organ circulation is weakening. A reduced gradient may compromise delivery of oxygen and nutrients and limit removal of metabolic waste, increasing concern for ischemic tissue injury. Clinicians use these changes alongside the clinical situation to determine whether circulation requires intervention or closer monitoring.