Central Nervous System
Central Nervous System - Related Videos
02:21
Generation of a Murine Model with a Central Nervous System Infection
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2025
This video demonstrates the generation of a mouse model with a CNS infection. A suckling pup is injected with the virus both intracranially and intraperitoneally. The virus spreads, infecting the CNS causing neuronal cell death and inflammation. The pup is assessed for symptoms of infection as the disease progresses.
10:28
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
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Cited by 11 •
2016
Optical clearing techniques are revolutionizing the way tissues are visualized. In this report we describe modifications of the original Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging-compatible Tissue-hYdrogel (CLARITY) protocol that yields more consistent and less expensive results.
05:04
Intrathecal Delivery of a Test Compound to the Rat Central Nervous System
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2025
Source: Chen, Y., et al. Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System. J. Vis. Exp. (2019)This video demonstrates the delivery of a test compound into the cerebrospinal fluid (CSF) through a catheter implanted in the lumbar spinal column of a rat model. The compound circulates along the CSF to the brain and spinal cord, enters neurons, and offers therapeutic potential.
20:51
Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE
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Cited by 19 •
2007
In this video we demonstrate how to isolate mononuclear cells from the central nervous system of rats with experimental autoimmune encephalomyelitis.
03:04
Extracellular Recording of Electrical Activity in the Drosophila Central Nervous System
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2025
The video demonstrates the extracellular recording of neuronal activity from the central nervous system (CNS) of Drosophila larvae. The transected CNS is positioned in a recording chamber, and the electrical activity from a descending nerve is recorded to establish the baseline firing frequency. A test agent is then introduced, and the change in firing frequency is recorded to determine the agent's excitatory or inhibitory effect.
FAQs
Coordination depends on several linked stages: sensory information enters neural circuits, interconnected neurons and glial cells help integrate those signals, and electrical impulses carry resulting commands. Chemical neurotransmitters support communication between cells. This sequence allows CNS activity to connect incoming information with movement, cognition, and essential physiological functions rather than treating each signal independently.
Neurons and glial cells participate in the interconnected networks that integrate information within the CNS. Neurons provide the signaling pathways through electrical impulses and chemical neurotransmitters, while glial cells are included in the cellular organization supporting signal integration. Studying both cell types helps neuroscience relate circuit structure to behavior, learning, and disease.
Neural circuits provide a framework for connecting cellular signaling with larger functions such as behavior and learning. By examining how interconnected elements process information and generate commands, researchers can investigate how CNS structure and function support these outcomes. Circuit-level analysis also helps relate changes in nervous system organization to neurological disease and injury.
These methods examine CNS organization and function from different but related perspectives. Electrophysiology addresses neural signaling, brain imaging helps investigate nervous system structure and function, and molecular analysis examines changes at the molecular level. Used together in neuroscience, they provide a broader account of how neural systems operate and how their structure or function changes.
CNS research can identify changes in nervous system structure and function associated with neurological disorders. Electrophysiology, brain imaging, and molecular analysis provide complementary evidence for examining those changes, while neural circuit studies connect them with altered behavior or other functions. These findings can clarify disease-related mechanisms and guide investigation of possible therapeutic approaches.
Research on the central nervous system supports investigation of how injury alters neural structure, function, and circuit activity. Neuroscience methods can characterize these changes and relate them to functional outcomes, creating a basis for studying rehabilitation. The same knowledge also contributes to therapeutic development aimed at neurological disorders and nervous system damage.