Gene Gain Loss

Gene gain and loss describes the evolutionary processes by which organisms acquire new genes or lose genes from their genomes, shaping genetic diversity and biological traits. Gene gain can occur through gene duplication, horizontal gene transfer, or the incorporation of novel genetic material, whereas gene loss commonly results from deletion, mutation, or relaxed selection. Comparing gene complements across species helps researchers reconstruct evolutionary relationships, identify lineage-specific adaptations, and examine how genomes change over time. In biology, studying these processes also clarifies the genetic basis of traits, ecological specialization, and differences in organismal function.

Gene Gain Loss - Related Videos

Research

JoVE Journal - Developmental Biology

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

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Cited by 2 •

2016

The goal of this protocol is to describe a loss- and gain-of function method that is applicable to identify neogenin as a stage-specific receptor that leads to trophectoderm and inner cell mass differentiation in preimplantation mouse embryos.

Education

JoVE Core - Cell Biology

Loss of Tumor Suppressor Gene Functions

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2023

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells. When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

Loss of Tumor Suppressor Gene Functions

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2021

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells. When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

Gain

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2024

Gain and phase shift are properties of linear circuits that describe the effect a circuit has on a sinusoidal input voltage or current. The circuit's behavior that contains reactive elements will depend on the frequency of the input sinusoid. As a result, it is observed that the gain and phase shift will all be frequency functions. Gain: Suppose Vin is the input and Vout is the output signal to a circuit. The input and output signals have the amplitude A and B and a phase angle of 0° and θ°,...

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

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Cited by 5 •

2013

While dsRNA feeding in C. elegans is a powerful tool to assess gene function, current protocols for large scale feeding screens result in variable knockdown efficiencies. We describe an improved protocol for performing large scale RNAi feeding screens that results in highly efficacious and reproducible knockdown of gene expression.

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