Intestinal Motility
Intestinal Motility - Related Videos
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Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines
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Cited by 26 •
2016
Recently available video recording and spatiotemporal mapping (STmap) techniques make it possible to visualize and quantify both propagating and mixing patterns of intestinal motility. The goal of this protocol is to explain the generation and analysis of STmaps using the GastroIntestinal Motility Monitoring (GIMM) system.
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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Cited by 32 •
2012
Postoperative ileus (POI) is a complication of abdominal surgery leading to increased morbidity and a prolonged hospital stay. Because prophylactic or therapeutic strategies are lacking intensified research is necessary. Therefore we established a standardized and feasible mouse model to investigate the pathophysiology of POI and to study potential therapeutic options.
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Gastrointestinal Motility Monitor (GIMM)
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Cited by 36 •
2010
Evaluation of colonic motility in the guinea pig distal colon with the Gastrointestinal Motility Monitor (GIMM) is a straightforward and simple to learn approach to quantitatively evaluate propulsive motility in the gastrointestinal tract.
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Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
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Cited by 63 •
2016
This article describes a video imaging technique and high-resolution spatiotemporal mapping to identify changes in the neural regulation of colonic motility in adult mice. Subtle effects on gastrointestinal (GI) function can be detected using this approach in isolated tissue preparations to advance our understanding of GI disease.
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An Introduction to Cell Motility and Migration
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2023
Cell motility and migration play important roles in both normal biology and in disease. On one hand, migration allows cells to generate complex tissues and organs during development, but on the other hand, the same mechanisms are used by tumor cells to move and spread in a process known as cancer metastasis. One of the primary cellular machineries that make cell movement possible is an intracellular network of myosin and actin molecules, together known as “actomyosin”, which creates a...
FAQs
Interstitial cells of Cajal provide pacemaker activity that helps organize the timing of smooth-muscle contractions. Their activity does not act alone: the enteric nervous system, autonomic signals, and hormones shape how contractions are coordinated. This interaction links the intestine’s intrinsic rhythmicity with regulatory inputs, helping explain how motility adjusts alongside secretion, digestion, and absorption.
Segmentation and peristalsis contribute differently to intestinal function. Segmentation repeatedly mixes intestinal contents, supporting ongoing interaction with processes involved in digestion and absorption. Peristalsis establishes forward movement toward the colon. Distinguishing these patterns helps researchers interpret whether a change primarily affects mixing, directional transit, or the coordination between the two.
Smooth-muscle contractions reflect the combined effects of intrinsic pacemaker activity, enteric nervous system control, autonomic signals, and hormones. These regulators can shape the coordination and pattern of movement rather than acting as isolated influences. Studying their interaction helps explain how intestinal motility remains integrated with broader gastrointestinal functions, including secretion and absorption.
Researchers can examine motility as part of a broader gastrointestinal physiology question, relating coordinated movement to transit, secretion, and absorption. This framing helps distinguish whether a change concerns movement itself or a linked digestive function. It also makes the topic useful for investigating altered gastrointestinal activity in constipation, diarrhea, and intestinal obstruction.
These conditions provide important contexts for examining how changes in coordinated intestinal movement affect gastrointestinal function. They can be studied to understand how transit and the handling of intestinal contents become altered relative to normal motility. Comparing such conditions with typical patterns supports research into the biological basis of motility disorders and their consequences.
Intestinal motility is a useful focus for pharmacology because it connects smooth-muscle activity and regulatory signaling with measurable gastrointestinal outcomes such as transit, secretion, and absorption. Research in this area can clarify how motility changes contribute to disorders and can support investigation of treatments intended to address abnormal intestinal movement.