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Chapters
- 00:05Title
- 01:14Operative Procedure and Postoperative Care
- 02:50Functional Studies Twenty-Four Hours Post Intestinal Manipulation
- 04:32Colon Transit Time
- 05:03Histochemical Analysis and Organ Culture of Muscularis Externa
- 07:25Representative Post Operative Ileus Results
- 09:15Conclusion
Postoperative ileus (POI) is a complication of abdominal surgery leading to increased morbidity and a prolonged hospital stay. Because prophylactic or therapeutic strategies are lacking intensified research is necessary. Therefore we established a standardized and feasible mouse model to investigate the pathophysiology of POI and to study potential therapeutic options.
Tags
Functional AssessmentIntestinal MotilityGut Wall InflammationRodentsStandardized ModelIntestinal ManipulationGastrointestinal TractHuman DiseasesAnimal Research ModelsCellular And MolecularIntestinal PathologyTunica MucosaMuscularis ExternaImmunocompetent OrganResident ImmunocytesInflammation Of The Bowel WallPostoperative IleusAbdominal SurgeryProinflammatory MediatorsIL-6IL-1βNitric Oxide (NO)Immunocytes ExtravasatePolymorphonuclear Neutrophils (PMN)MonocytesIntestinal ParalysisIncreased Risk Of AspirationBacterial TranslocationInfectious ComplicationsSepsisMulti Organ Failure
