Specimen Holder
Specimen Holder - Related Videos
07:15
A Novel Method for In Situ Electromechanical Characterization of Nanoscale Specimens
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Cited by 2 •
2017
Isolating electrical and thermal effects on electrically assisted deformation (EAD) is very difficult using macroscopic samples. Metallic sample micro- and nanostructures together with a custom test procedure have been developed to evaluate the impact of applied current on the formation without joule heating and evolution of dislocations on these samples.
08:12
Brain Banking: Making the Most of your Research Specimens
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Cited by 21 •
2009
Brain banking and systematic sampling of biological material provides the basis for unbiased stereology and maximizes the potential data obtained from each specimen.
07:19
Simulating Fall-Induced Wrist Fractures Using a Cadaveric Human Forearm Specimen
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2026
Source:Anthony J. Yosick1,2, Christine Massie1, Emma Knapp2, Hani A. Awad1,2,31Department of Biomedical Engineering, University of Rochester, US2Center for Musculoskeletal Research, Department of Orthopedics, University of Rochester Medical Center, USA3Department of Orthopedics, University of Rochester Medical Center, USAThe video demonstrates fall-related wrist fractures using human cadaver forearms with varying bone densities. Specimens are standardized by removing upper soft tissue,...
10:54
Cryo-electron Microscopy Specimen Preparation By Means Of a Focused Ion Beam
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Cited by 5 •
2014
Cryo Electron Microscopes, either Scanning (SEM) or Transmission (TEM), are widely used for characterization of biological samples or other materials with a high water content1. A SEM/Focused Ion Beam (FIB) is used to identify features of interest in samples and extract a thin, electron-transparent lamella for transfer to a cryo-TEM.
07:55
An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering
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Cited by 4 •
2019
A novel sample holder for macromolecular X-ray crystallography along with a suitable handling protocol is presented. The system allows crystal growth, crystal soaking and in situ diffraction data collection at both, ambient and cryogenic temperature without the need of any crystal manipulation or mounting.
FAQs
By constraining movement while a sample is prepared or examined, the holder helps keep the intended region facing the sectioning, staining, imaging, or measurement system. Maintaining this orientation allows researchers to return to the same tissue area and compare observations more consistently, which is especially important when evaluating cellular structure or changes across related samples.
Different workflows may involve tissue biopsies, tumor specimens, cell preparations, or other sample formats, and each may require compatible support and positioning. Selecting a holder suited to both the material and the platform helps keep the sample accessible and aligned for the planned preparation or analysis, reducing handling problems that could affect evaluation.
Stable handling reduces unintended sample movement and damage during preparation and analysis. This supports more reproducible observations of cellular structure, biomarker distribution, and treatment-related changes. When samples remain consistently positioned, differences seen between measurements are more likely to reflect the biological material or experimental treatment rather than variation introduced by handling.
The workflow begins by selecting a holder appropriate for the sample format and intended analytical platform. Researchers then position the biopsy, tumor specimen, cell preparation, or other material so the relevant region remains accessible, secure it, and maintain that alignment through preparation and measurement. The same positioning principle supports sectioning, staining, microscopy, and instrument-based analysis.
A holder can support several stages of cancer research workflows, including tissue sectioning, staining, microscopy, and instrument-based measurements. It may be used with tumor specimens, tissue biopsies, or cell preparations, depending on the procedure and platform. Its contribution is most relevant when researchers need stable access to a defined sample region during preparation or examination.
Consistent handling helps researchers evaluate cellular structure, biomarker distribution, and treatment-related changes with greater reproducibility. Keeping samples aligned and minimizing damage also supports comparisons among observations made during preparation, imaging, or measurement. In cancer research, these outcomes help maintain a reliable connection between the region examined and the biological or treatment-related feature being evaluated.