Conjugated Compounds

Conjugated compounds are molecules containing alternating single and multiple bonds that allow electrons to spread across neighboring atoms, giving these structures distinctive chemical and physical properties. Their behavior arises from continuous overlap of p orbitals, which creates a delocalized π-electron system and can lower the molecule’s overall energy; extended conjugation often shifts light absorption toward longer wavelengths. In chemistry, conjugated compounds are important in organic synthesis, spectroscopy, and materials science, where their color, stability, and electronic behavior support applications ranging from biological chromophores and pharmaceuticals to dyes, organic semiconductors, and solar-energy materials.

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Education

JoVE Core - Organic Chemistry

Conjugate Addition to α,β-Unsaturated Carbonyl Compounds

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2025

α,β-Unsaturated carbonyl compounds are molecules bearing a carbonyl and alkene functionality in conjugation with each other. The conjugation in the molecule leads to three resonance structures. The hybrid form exhibits two probable electrophilic sites: the carbonyl carbon and the β carbon. A simple nucleophilic attack at the carbonyl center results in an alkoxy intermediate, which gives the direct or 1,2-addition product upon further protonation. When the nucleophile attacks the β carbon, it...

Research

JoVE Journal - Chemistry
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Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds

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Cited by 4 •

2018

A protocol of step-by-step Raman and IR spectroelectrochemical analysis is presented.

Conjugated Proteins

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2020

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties. Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...

Conjugation

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2025

Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...

Mechanism of Conjugation

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2025

Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...

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