Nano Drug Synthesis
Nano Drug Synthesis - Related Videos
13:29
Biodistribution of Nano-drug Carriers: Applications of SEM
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2023
Source: Peiman Shahbeigi-Roodposhti and Sina Shahbazmohamadi, Biomedical Engineering Department, University of Connecticut, Storrs, Connecticut Nanoparticles have been increasingly used research towards targeted drug delivery and controlled drug release. While most of these particles have been developed as polymeric or liposomal particles because of their biocompatibility, there is a trend in current research toward the use of metallic and magnetic nanoparticles. These metallic nanoparticles...
01:29
Drugs Affecting Neurotransmitter Synthesis
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2025
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
10:23
Synthesis and Functionalization of 3D Nano-graphene Materials: Graphene Aerogels and Graphene Macro Assemblies
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Cited by 5 •
2015
This video method describes the synthesis of high surface area, monolithic 3D graphene-based materials derived from polymer precursors as well as single layer graphene oxide.
04:38
Turbidimetric Limulus Amoebocyte Lysate Assay: A Technique to Detect and Quantify Endotoxin Contamination in Nano-Formulated Drugs
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2025
This video describes the turbidimetric format of the Limulus amoebocyte lysate, or LAL, assay to estimate endotoxin contamination in PEGylated liposomal doxorubicin nano-formulations. The turbidity of the solution following the reaction of the endotoxin with the LAL reagent helps to estimate the endotoxin in the sample.
14:20
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Cited by 23 •
2014
An example of a nano drug based on polymalic acid is presented towards the rational design of personalized medicine that is applicable to cancer. It describes the synthesis of a nano drug to treat Her2-positive human breast cancer in a nude mouse.
FAQs
Self-assembly allows drug-containing components to organize into nanoscale structures through interactions among the active compound, polymers, lipids, or inorganic materials. The resulting arrangement depends on the composition and surface properties of the components. Controlling these interactions helps researchers produce particles with characteristics suited to drug transport, stability, or controlled release rather than simply combining the ingredients without structural organization.
Solvent conditions, component concentration, temperature, and mixing influence how materials combine and when particles form. Changes in these variables can alter particle size, composition, and surface properties. In chemistry-based formulation work, systematic adjustment of these conditions helps researchers control the formation process and identify settings that produce a reproducible material with the desired drug-delivery characteristics.
Controlled precipitation forms particles by managing the conditions under which components come out of solution, whereas emulsification uses dispersed phases to combine materials during formulation. Both approaches require control of solvent conditions, concentration, temperature, and mixing, but they rely on different formation processes. Comparing these routes helps researchers select a preparation strategy appropriate for the materials and intended formulation properties.
A typical workflow begins by selecting the active compound and supporting materials, such as polymers, lipids, or inorganic components. Researchers then choose a formation approach, adjust solvent conditions, concentration, temperature, and mixing, and produce the drug-containing particles. Finally, they characterize size, structure, and composition to determine whether the formulation meets its intended performance and quality requirements.
Characterization connects the preparation conditions with the material that was produced. Measurements of particle size, structure, and composition show whether the formulation has the expected physical and chemical features. These results guide optimization by revealing how changes in synthesis or formulation affect the product, while also supporting quality assessment before researchers evaluate its usefulness for drug delivery.
These methods support delivery systems intended to improve drug solubility, stability, transport, or controlled release. Chemistry researchers can vary the particle components and preparation conditions, then relate those choices to measured size, structure, and composition. This approach provides a formulation-oriented way to investigate how nanoscale material properties influence the behavior and potential performance of a therapeutic system.