Disintegrant
Disintegrant - Related Videos
02:48
Radioactive Decay and Radiometric Dating
0 Views •
2020
Radioactivity is a spontaneous disintegration of an unstable nuclide and is a random process, as all the nuclei in the sample do not decay simultaneously. The number of disintegrations per unit time is called the activity (A), which is directly proportional to the number of nuclei in the sample. The decay constant (λ) is an average probability of decay per nucleus in unit time. The SI unit for activity is the becquerel, which is one disintegration per second. Another unit of activity is the...
11:20
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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Cited by 1 •
2017
In this protocol, caged protein kinase A (PKA), a cellular signal transduction bioeffector, was immobilized on a nanoparticle surface, microinjected into the cytosol, and activated by the upconverted UV light from near-infrared (NIR) irradiation, inducing downstream stress fiber disintegration in the cytosol.
14:48
Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
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Cited by 35 •
2012
We describe the rapid isolation of primary murine type II alveolar epithelial cells (AECII) by flow cytometric negative selection. These AECII show high viability and purity and are suitable for a wide range of functional and molecular studies regarding their role in respiratory conditions such as autoimmune or infectious diseases.
06:50
Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening
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Cited by 1 •
2025
Here, we establish a metabolic profiling platform integrating three-dimensional (3D) glioma spheroids and imaging-based normalization via extracellular flux analysis. This approach enables more accurate assessment of tumor metabolic responses to drug treatments and provides insights into potential mechanisms of resistance.
02:15
Nanoblade-Based Delivery of Nucleic Acid Cargo: A Technique to Deliver Cas9-sgRNA Complex to Target Cells via Virus-Like Particles
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2025
This video demonstrates a technique for nanoblade-based delivery of Cas9-sgRNA ribonucleoprotein complex inside target cells for genome editing. Nanoblades are virus-like particles devoid of the ability to multiply and infect neighboring cells, therefore are very useful for rapid and dose-dependent transportation of bio- and nanomaterials.
FAQs
Swelling increases the volume of disintegrant particles after they contact gastrointestinal fluids, while liquid wicking draws fluid into the tablet or capsule structure. These actions weaken internal particle interactions and promote fluid penetration throughout the dosage form. Together, they can accelerate breakup into smaller particles, supporting more reliable subsequent drug release.
During manufacture, particles may deform and contribute to the compact structure of a tablet. When exposed to gastrointestinal fluids, recovery of that deformed structure can generate forces that disrupt the dosage form. This mechanism works alongside swelling and liquid wicking, helping explain why disintegrant behavior depends on how particles contribute to both tablet formation and breakup.
A formulation must remain sufficiently strong during handling and storage while still breaking apart within an appropriate time after fluid contact. Increasing structural strength can make breakup more difficult, whereas prioritizing rapid disintegration may affect the dosage form’s integrity or stability. Testing therefore evaluates disintegration, dissolution, tablet strength, and stability together rather than treating one result as sufficient.
Developers select a disintegrant according to how its swelling, wicking, deformation, or recovery behavior affects the dosage form. They then test the formulation for disintegration time, dissolution, tablet strength, and stability. Reviewing these results together helps identify a composition that breaks apart consistently while maintaining adequate physical integrity and supporting reliable drug release.
Disintegration time indicates how quickly the dosage form breaks apart after fluid contact, while dissolution testing examines the subsequent release of the active ingredient. Tablet strength and stability provide complementary information about handling and storage performance. Considering all four measurements helps quality control detect formulations that release inconsistently or sacrifice durability for rapid breakup.
Their performance can influence how consistently an active ingredient becomes available for absorption after an oral dose. If a tablet or capsule does not break apart reliably, drug release may vary even when the dosage form contains the intended ingredients. For clinical drug development, controlling disintegrant behavior therefore supports consistent performance of oral solid dosage forms.