Ventricular Fibrillation
Ventricular Fibrillation - Related Videos
09:47
A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
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Cited by 26 •
2015
This article describes a rat model of electrically-induced ventricular fibrillation and resuscitation by chest compression, ventilation, and delivery of electrical shocks that simulates an episode of sudden cardiac arrest and conventional cardiopulmonary resuscitation. The model enables gathering insights on the pathophysiology of cardiac arrest and exploration of new resuscitation strategies.
07:56
A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
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2023
This protocol presents a model of long-term ventricular fibrillation in rat hearts induced by continuous stimulation with low-voltage alternating current. This model has a high success rate, is stable, reliable, and reproducible, has a low impact on cardiac function, and causes only mild myocardial injury.
03:03
Amyloid Fibrils
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2020
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
05:36
Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
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Cited by 7 •
2020
Cardiopulmonary resuscitation and defibrillation are the only effective therapeutic options during cardiac arrest caused by ventricular fibrillation. This model presents a standardized regimen to induce, assess, and treat this physiological state in a porcine model, thus providing a clinical approach with various opportunities for data collection and analysis.
11:21
Robotic Ablation of Atrial Fibrillation
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Cited by 12 •
2015
Pulmonary vein isolation (PVI) with an ablation catheter is a curative treatment for atrial fibrillation (AF). Robotic catheter systems aim to improve catheter steerability. Here, a procedure with a new robotic catheter system is presented. The goal of the procedure is electrical block between pulmonary vein and left atrium.
FAQs
Ventricular fibrillation can be sustained by multiple reentrant wavelets, meaning electrical activation repeatedly circulates through ventricular tissue rather than following a coordinated pattern. These interacting wavelets keep depolarization disorganized, so the ventricles cannot produce an effective contraction. This mechanism explains why the rhythm persists and why restoring organized electrical activity is central to treatment.
The characteristic irregular electrocardiogram reflects the underlying electrical disorder rather than a coordinated ventricular rhythm. Because ventricular depolarization is disorganized, the tracing does not represent an effective sequence of contractions. In clinical assessment, recognizing this pattern supports rapid identification of the emergency, allowing resuscitative measures and defibrillation to begin without delay.
Loss of effective ventricular contraction abruptly eliminates cardiac output, so blood is no longer being circulated adequately by the heart. The resulting clinical deterioration is rapid: without immediate treatment, the patient can lose consciousness and die. This makes ventricular fibrillation a time-critical emergency in which delays threaten restoration of effective circulation.
Unsynchronized defibrillation is intended to reset the ventricles’ electrical activity when chaotic activation prevents an effective contraction. By applying this intervention promptly, clinicians aim to stop the disorganized rhythm and allow organized cardiac activity to return. Its role is distinct from later preventive care, which focuses on reversible causes and reducing recurrence.
Management begins with early recognition, followed by cardiopulmonary resuscitation and prompt unsynchronized defibrillation. CPR provides immediate resuscitative support while defibrillation addresses the abnormal ventricular electrical activity. Together, these steps target the two urgent problems: loss of effective cardiac output and the disorganized rhythm causing it, making rapid action essential.
Once the immediate rhythm problem has been treated, subsequent care addresses reversible causes associated with ventricular fibrillation. Clinicians also plan measures to reduce recurrence, selecting among medications, procedures, or an implantable cardioverter-defibrillator. Thus, treatment extends beyond restoring rhythm and includes addressing contributing factors and limiting the chance of future episodes.
An implantable cardioverter-defibrillator is one of the longer-term options named for reducing the risk of recurrence after ventricular fibrillation. It belongs to preventive care rather than the immediate resuscitation sequence. The broader follow-up strategy may also include medications or procedures, with the selected approach directed toward lowering the chance that another episode will occur.