Ventricular Dilation

Ventricular dilation is the abnormal enlargement of a ventricle, a fluid- or blood-containing chamber, and is an important clinical sign rather than a diagnosis by itself. In the heart, chronic pressure or volume overload can stretch a ventricular wall and increase chamber size; in the brain, impaired cerebrospinal fluid circulation can enlarge the cerebral ventricles. Clinicians assess ventricular dilation with echocardiography, ultrasound, computed tomography, or magnetic resonance imaging, depending on the organ involved. Its pattern and severity help identify underlying disease, evaluate functional consequences, guide treatment, and monitor progression or response to intervention.

Ventricular Dilation - Related Videos

Education

JoVE Core - Medical-Surgical Nursing

Cardiomyopathy II: Dilated Cardiomyopathy

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2025

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Research

JoVE Journal - Medicine

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

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Cited by 4 •

2018

Here, we present a protocol using two centrifugal pumps as a total artificial heart replacement.

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

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Cited by 34 •

2014

Right ventricle (RV) dysfunction is critical to the pathogenesis of cardiovascular disease, yet limited methodologies are available for its evaluation. Recent advances in ultrasound imaging provide a noninvasive and accurate option for longitudinal RV study. Herein, we detail a step-by-step echocardiographic method using a murine model of RV pressure overload.

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

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Cited by 22 •

2015

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

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Cited by 15 •

2013

Kv channel dysfunction is associated with cardiac arrhythmias. In order to study the molecular mechanisms that lead to such arrhythmias we utilize a systematic protocol for isolation of atrial and ventricular cardiomyocytes from Kv channel ancillary subunit knockout mice. Isolated cardiomyocytes can then immediately be used for cellular electrophysiological studies, biochemical or immunofluorescence (IF) assays.

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