Obesity Induction
Obesity Induction - Related Videos
01:24
Obesity
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2024
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
11:33
Inductance
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2023
Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN This experiment will use inductive coils to demonstrate the concept of inductor and inductance. Magnetic induction will be demonstrated using a rod magnet inserted into or extracted away from the core of a coil to induce a transient electromotive force (emf) voltage in the coil, measured by a voltmeter. This experiment will also demonstrate the mutual inductance between...
13:09
Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Cited by 26 •
2012
Fat content analysis is routinely conducted in studies utilizing murine obesity models. Emerging methods in small animal CT imaging and analysis are providing for longitudinal detail rich fat content analysis. Here we detail step by step procedures for performing small animal CT imaging, analysis, and visualization.
14:01
Anesthesia Induction and Maintenance
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2016
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN The Guide for the Care and Use of Laboratory Animals ("The Guide") states that pain assessment and alleviation are integral components of the veterinary care of laboratory animals. The definition of anesthesia is the loss of feeling or sensation. It is a dynamic event involving changes in anesthetic depth with respect to an animal's metabolism, surgical stimulation, or variations in the...
05:18
Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
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Cited by 1 •
2024
This study explores acupoint catgut embedding therapy for obesity, covering patient management, material preparation, acupoint selection, surgery, and post-operative care.
FAQs
The central experimental variable is sustained energy imbalance. Calorie-dense diets or altered feeding conditions can increase energy intake, while biological or experimental changes that reduce expenditure can reinforce adiposity. Separating these contributions helps researchers determine whether a phenotype reflects excess consumption, reduced energy use, or both, which is important when comparing genetic susceptibility across experimental groups.
Leptin and insulin pathways connect adipose tissue and nutrient status with appetite regulation and metabolism. Disrupted signaling can alter feeding behavior or metabolic control, helping explain why organisms with similar exposure may develop different degrees of adiposity. Examining these pathways allows genetics researchers to link inherited differences with physiological responses during obesity induction.
Adipocyte development provides a cellular perspective on increasing adiposity. Genetic and metabolic factors can influence how adipose tissue forms and expands during an experimental exposure. Assessing this process alongside body-weight or adiposity changes helps investigators distinguish mechanisms related to tissue development from those involving appetite, energy expenditure, or broader metabolic regulation.
Researchers can compare organisms with different genetic backgrounds under the same dietary or feeding conditions, or examine a shared genotype across contrasting exposures. Differences in adiposity or metabolic responses then help identify interactions between inherited variants and environmental inputs. This design is useful for determining why a diet or feeding condition produces stronger effects in some groups than others.
Common approaches described for these models include calorie-dense diets, altered feeding conditions, and genetic manipulation. The selected approach depends on whether the study emphasizes increased energy intake, disrupted appetite signaling, reduced expenditure, or inherited susceptibility. Maintaining a sustained exposure is essential for producing the adiposity needed to investigate biological and genetic responses.
These models can be used to examine increased adiposity together with pathways involving leptin, insulin, adipocyte development, and metabolism. Such outcomes help connect an observable obesity-related phenotype with underlying biological regulation. In genetics studies, comparisons among experimental organisms can further show how variants influence susceptibility and how environmental conditions modify the resulting response.
Once sustained adiposity and related metabolic changes have been established, the models provide a framework for evaluating interventions aimed at obesity or its complications. Researchers can assess whether an intervention affects appetite-related signaling, adipose biology, metabolism, or the broader phenotype. Genetic context also helps determine whether responses differ according to inherited susceptibility.