Hepatic Artery Injection
Hepatic Artery Injection - Related Videos
04:46
Targeting Liver Tumors with Oncolytic Viruses via the Hepatic Artery
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2025
The video demonstrates locoregional delivery of oncolytic viruses through hepatic arterial injection as a therapeutic approach for hepatocellular carcinoma. These viruses selectively replicate in tumor cells, inducing cell lysis and releasing tumor cell-associated antigens. This process triggers immunogenic cell death, inducing an anti-tumor response.
18:47
Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction
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Cited by 22 •
2013
Orthotopic liver transplantation in rats is an indispensable experimental model for biomedical research. Here we present our surgical procedures for orthotopic rat liver transplantation with hepatic arterial reconstruction using a 50% partial graft.
16:19
Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Cited by 5 •
2014
Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.
07:41
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
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Cited by 47 •
2011
Numerous genetic manipulations and/or intramyocardial injections of genes, proteins, cells, and/or biomaterials are superimposed upon the dimension of time in studies of acute ischemia/ reperfusion injury and chronic remodeling in mice. This video illustrates the microsurgical procedures for ischemia/reperfusion, permanent coronary artery ligation, and intramyocardial injection studies.
07:00
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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Cited by 43 •
2016
This manuscript provides the detailed procedure of intra-iliac artery (IIA) injection, a technique to deliver cancer cells specifically to hind limb tissues including bones to establish experimental bone metastases. Although initially established with breast tumor models, this protocol can be easily extended to other cancer types.
FAQs
Hepatic artery injection relies on arterial blood flow to carry the introduced material through branching vessels, increasing contact with liver tissue after placement in the arterial supply. This distribution is important because exposure can remain focused on the liver rather than being treated only as a systemic event. Researchers can therefore examine tissue-specific delivery and dose-dependent hepatic responses.
The delivered material can expose both hepatocytes and resident immune cells within the liver. Hepatocytes provide a key tissue target for evaluating biological or treatment effects, while resident immune cells help reveal local immune activation and inflammatory responses. Considering these populations together supports analysis of how hepatic tissue and its immune environment respond to pathogens, drugs, or other test materials.
Dose and distribution influence how strongly liver tissue is exposed and help researchers distinguish delivery effects from biological responses. Controlled comparisons can show whether different amounts produce changes in immune activation, pathogen-related interactions, or inflammation. Examining distribution alongside dose also clarifies whether an observed outcome reflects localized hepatic exposure or uneven access within the liver.
The essential workflow places a needle or catheter in the hepatic artery and introduces the selected cells, pathogens, drugs, or other test material into the arterial supply. Blood flow then carries the material through branching vessels toward liver tissue. Subsequent observations can focus on distribution, hepatocyte effects, resident immune-cell responses, immune activation, or inflammation.
Researchers may choose this approach when they need to model exposure centered in the liver and investigate host responses at that site. It can support studies of host-pathogen interactions, localized immune activation, and inflammatory outcomes. The method also allows treatment effects to be assessed in hepatic tissue, where responses may differ from those produced by less localized delivery.
Studies can compare how dose, material distribution, and tissue exposure relate to hepatic outcomes. Relevant observations include immune activation, inflammatory responses, host-pathogen interactions, and tissue-specific treatment effects. These comparisons help connect the way a test material reaches the liver with the biological response that follows, supporting more focused interpretation of experimental results.