Multi-pronged Device
Multi-pronged Device - Related Videos
07:55
A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device
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Cited by 5 •
2010
A microfluidic islet perifusion device was developed for the assessment of dynamic insulin secretion of multiple islets and simultaneous fluorescence imaging of calcium influx and mitochondrial potential changes.
10:18
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
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Cited by 26 •
2017
Multilayer microfluidic devices often involve the fabrication of master molds with complex geometries for functionality. This article presents a complete protocol for multi-step photolithography with valves and variable height features tunable to any application. As a demonstration, we fabricate a microfluidic droplet generator capable of producing hydrogel beads.
09:45
Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
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Cited by 8 •
2011
Dielectrophoresis (DEP) is an effective method to manipulate cells. Printed circuit boards (PCB) can provide inexpensive, reusable and effective electrodes for contact-free cell manipulation within microfluidic devices. By combining PDMS-based microfluidic channels with coverslips on PCBs, we demonstrate bead and cell manipulation and separation within multichannel microfluidic devices.
08:29
Thermal Measurement Techniques in Analytical Microfluidic Devices
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Cited by 6 •
2015
Here, we present three protocols for thermal measurements in microfluidic devices.
09:32
Long-Term Culture and Monitoring of Isolated Caenorhabditis elegans on Solid Media in Multi-Well Devices
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Cited by 3 •
2022
Presented here is an optimized protocol for culturing isolated individual nematodes on solid media in microfabricated multi-well devices. This approach allows individual animals to be monitored throughout their lives for a variety of phenotypes related to aging and health, including activity, body size and shape, movement geometry, and survival.
FAQs
Coordinated interfaces assign different functions to distinct parts of the system while allowing those functions to operate together. One interface may collect a sample, another may deliver a material, and another may detect a biological signal or control local conditions. This arrangement helps connect interventions with measurements, so researchers can examine related events within one experimental system.
Parallel functions allow host responses, pathogen activity, and treatment effects to be examined in the same integrated setting. Rather than treating each measurement as an isolated result, researchers can relate signals or changes produced by different device components. That linked information may provide more context for interpreting interactions between infection, immunity, and therapeutic effects.
Controlling local conditions gives the device a way to manage the environment around a biological process while other components collect samples or detect signals. Because the design can combine environmental control with observation, researchers may assess how changing conditions influences host responses, pathogen behavior, or treatment outcomes. The value depends on which functions the specific device incorporates.
Separate instruments generally divide collection, delivery, detection, and control into independent activities. An integrated platform links selected functions within one system, reducing the need to transfer work between instruments. This can improve experimental efficiency and preserve relationships among measurements, although the available functions remain dependent on the device design and its component interfaces.
Planning begins by identifying the biological tasks that must occur together, such as sample collection, material delivery, signal detection, or control of local conditions. Researchers then match those tasks to the device’s components or interfaces and determine which host, pathogen, or treatment-related measurements should be connected. The resulting configuration should reflect the intended experimental question.
This approach is useful when a study must examine several connected aspects of infection or treatment rather than a single measurement. It can support integrated analysis of host responses, pathogen activity, and treatment effects within the same platform. Such studies may contribute to diagnostic, therapeutic, or research tools, depending on the device’s functions and intended application.
A multi-pronged platform can produce linked information about biological signals, collected samples, delivered materials, and controlled local conditions. Combining these outputs may reveal relationships that are less apparent when measurements are collected separately. In infection research, the resulting data can support more context-rich evaluation of immune responses, pathogen activity, and the effects of treatment.
By combining several measurements or interventions, the platform can help researchers evaluate biological status and treatment effects within a coordinated experiment. That broader evidence may inform the development of diagnostic tools that analyze infection-related responses or therapeutic tools that deliver and assess interventions. Its contribution depends on the functions incorporated into the particular device design.