Lisa Impactor
Lisa Impactor - Related Videos
03:24
Generating a Mouse Model of Traumatic Brain Injury Using an Impactor Device
0 Views •
2025
This video demonstrates the procedure for inducing traumatic brain injury (TBI) in a mouse model. An anesthetized mouse with an exposed skull is taken to create an opening in the skull, and then a controlled cortical injury is induced using an impact device. The injury damages the brain tissue, causing impaired cognitive function and motor coordination.
03:58
Generating a Traumatic Brain Injury Mouse Model Using an Impactor Probe
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2025
This video demonstrates the procedure for inducing an open-skull traumatic brain injury in a mouse by making a midline skull incision, drilling through the skull and removing the bone flap to expose the brain cortex, and applying high pressure to induce trauma. The wound is then sutured to prepare the mouse model for subsequent experiments.
07:14
Investigating the 'Uncatchable Smile' in Leonardo da Vinci's La Bella Principessa: A Comparison with the Mona Lisa and Pollaiuolo's Portrait of a Girl
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Cited by 3 •
2016
This paper discusses the methodology used to reveal the 'Uncatchable Smile' illusion in Leonardo da Vinci's La Bella Principessa portrait. A combination of three methods was used (inter-observation, structured interviews, and psychophysical experiments), which led to an investigation that shaped itself without prior beliefs, thus reducing potential researcher bias.
07:28
A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
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Cited by 46 •
2012
A reliable and repeatable way to produce a cervical unilateral spinal cord injury using the Infinite Horizon impactor is described. The method takes advantage of a custom designed frame and clamp to stabilize the spine. The standardized procedure and biomechanical injury parameters result in sufficient and sustained injuries.
06:31
Automated Impactor for Contusive Spinal Cord Injury Model in Mice
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Cited by 6 •
2024
Presented here is a novel automated spinal cord injury contusion device for mice, which can accurately produce spinal cord injury contusion models with varying degrees.
FAQs
These parameters determine how the mechanical insult is calibrated and help researchers produce different, reproducible injury severities. Controlling them reduces unwanted variation between experimental groups, making biological differences easier to attribute to the injury condition. This is important when examining how tissue damage, inflammation, neurological dysfunction, and recovery change across standardized injury settings.
Reproducibility allows investigators to compare results across animals, experimental groups, and recovery periods with greater confidence. Because the impact conditions are controlled, observed differences in tissue responses or neurological outcomes are less likely to arise from inconsistent injury delivery. This consistency strengthens studies of injury mechanisms, biomarkers, and candidate neuroprotective treatments.
Studies can follow several consequences over time, including tissue damage, inflammation, neurological dysfunction, and recovery. Examining these outcomes together helps connect the initial mechanical injury with later biological and functional changes. The model therefore supports both short-term assessment of injury effects and longitudinal investigation of how those effects evolve.
By delivering a calibrated impact under controlled conditions, the system creates a consistent starting point for studying injury-related changes. Researchers can then relate the imposed mechanical conditions to tissue damage, inflammatory responses, neurological dysfunction, and recovery. This controlled relationship helps clarify how mechanical injury contributes to biological consequences in experimental medicine.
The experiment controls the impact location and the mechanical delivery parameters. Depending on the model, the calibrated impact is applied to the skull or to an exposed brain surface, while velocity, depth, and duration are specified. Maintaining these conditions helps generate consistent injury severities and supports meaningful comparisons between experimental groups.
Researchers use this model when they need a controlled platform for studying traumatic brain injury and its consequences before clinical studies. It can support investigations of injury mechanisms, biomarker evaluation, and testing of potential neuroprotective treatments. Results may also be followed through recovery, allowing investigators to assess how biological and neurological effects change over time.