Physiologically Relevant Setting
Physiologically Relevant Setting - Related Videos
10:45
A Community-based Stress Management Program: Using Wearable Devices to Assess Whole Body Physiological Responses in Non-laboratory Settings
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Cited by 1 •
2018
Stress is an unavoidable and persistent component of life and holistic approaches for its management are being considered. A standardized methodology was created to demonstrate the feasibility of a breath-based stress management protocol that can be used with commercially available portable technology.
09:54
A Model to Simulate Clinically Relevant Hypoxia in Humans
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Cited by 1 •
2016
Hypoxia simulation in humans has usually been performed by inhaling hypoxic gas mixtures. For this study, apneic divers were used to simulate dynamic hypoxia in humans. Additionally, physiological changes in desaturation and re-saturation kinetics were evaluated with non-invasive tools such as Near-Infrared-Spectroscopy (NIRS) and peripheral oxygenation saturation (SpO2).
09:02
Building and Operating a Low-Cost Elevated Carbon Dioxide Growth Chamber to Evaluate Microgreen Physiology under Spaceflight-Relevant CO2 Levels
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2026
This protocol describes how to construct and operate a small, low-cost growth chamber capable of maintaining extreme carbon dioxide (exCO2) levels for plant experiments. The chamber enables reproducible studies of microgreen physiology under spaceflight-relevant atmospheric conditions, using a single-board computer-based monitoring and control system and a passive hydroponic wicking system.
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Physiology of the Circulatory System - Concepts
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2019
Homeostasis Conditions in the external environment of an organism can change rapidly and drastically. To survive, organisms must maintain a fairly constant internal environment, which involves continuous regulation of temperature, pH, and other factors. This balanced state is known as homeostasis, which describes the processes by which organisms maintain their optimal internal conditions. To maintain homeostasis, organisms have developed structures with distinct functions. Physiology is the...
11:55
Physiological Correlates of Emotion Recognition
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2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California The autonomic nervous system (ANS) controls the activity of the body's internal organs and regulates changes in their activity depending on the current environment. The vagus nerve, which innervates many of the internal organs, is an important part of the system. When our brain senses danger, vagal tone is inhibited, leading to a set of changes in the body designed to make us more prepared to fight or...
FAQs
The outcome depends on the combined control of temperature, pH, oxygen availability, nutrient levels, extracellular matrix composition, fluid flow, and mechanical forces. These variables influence cell behavior and tissue function, so changing one condition may alter how a model responds to disease-related processes or treatments. Researchers therefore interpret findings in relation to the specific physiological conditions reproduced.
Extracellular matrix composition and mechanical forces provide environmental signals that can modify cell behavior and tissue function. Including these features makes the experimental context more representative than one that controls only basic culture conditions. Their presence is especially relevant when researchers evaluate how tissues respond to disease models or therapeutic strategies under conditions intended to approximate living biology.
Oxygen availability, pH, and nutrient levels are regulated because they are key conditions found in living tissues and can influence cellular responses. Controlling them helps researchers examine outcomes under a defined physiological context rather than relying on simplified laboratory conditions alone. This can improve interpretation of findings from disease modeling, drug screening, and toxicity testing.
A simplified laboratory system may not reproduce the range of environmental factors that shape human biology. A physiologically relevant setting narrows this gap by incorporating conditions such as extracellular matrix composition, fluid flow, and mechanical forces alongside temperature, pH, oxygen, and nutrients. The resulting findings may offer more representative evidence for interpreting preclinical disease or treatment responses.
Researchers first identify the tissue conditions important to the question, then regulate the selected variables, including temperature, pH, oxygen availability, nutrients, matrix composition, fluid flow, or mechanical forces. They subsequently examine effects on cell behavior or tissue function and interpret the results within that controlled context. This workflow supports more consistent and biologically representative experimental comparisons.
These settings are useful for building more realistic disease models, screening drugs, testing toxicity, and evaluating therapeutic strategies. By exposing cells or tissues to controlled conditions that better reflect living biology, researchers can assess responses in a context closer to human physiology. The approach may improve the interpretation, reproducibility, and translational value of preclinical research.