Pulmonary Physiology
Pulmonary Physiology - Related Videos
05:35
Imaging Ca2+ Signals in Small Pulmonary Veins at Physiological Intraluminal Pressures
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2025
In this protocol, we present a novel technique for recording and analyzing Ca2+ signals in intrapulmonary veins (small pulmonary veins or PVs) at physiological intraluminal pressures. The technique involves isolating small PVs, incubating them with a Ca2+ indicator, cannulating and pressurizing them, confocal imaging of Ca2+ signals, and data analysis.
08:17
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Cited by 8 •
2017
The following protocol describes the methodology for the acquisition and analysis of echocardiographic images used to obtain the Left Atrial Volume (LAV), Aorta (Ao) diameter, and Pulmonary Artery (PA) diameter in mice. This technique is a non-invasive, non-terminal procedure that allows assessment of the cardiopulmonary function.
05:33
Physiology of the Circulatory System - Concepts
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2019
Homeostasis Conditions in the external environment of an organism can change rapidly and drastically. To survive, organisms must maintain a fairly constant internal environment, which involves continuous regulation of temperature, pH, and other factors. This balanced state is known as homeostasis, which describes the processes by which organisms maintain their optimal internal conditions. To maintain homeostasis, organisms have developed structures with distinct functions. Physiology is the...
04:19
Pressure Fixation of Isolated Murine Pulmonary Valve: A Procedure to Isolate and Chemically Fix the Mouse Pulmonary Valve in Closed Conformation
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2025
In this video, we describe the procedure to isolate and chemically fix the mouse pulmonary value in closed conformation via perfusion pressurization.
06:59
Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
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2025
Pulmonary vein stenosis (PVS) is a life-threatening complication of fibrosing mediastinitis (FM), with a poor prognosis if not properly treated. Currently, catheter-based endovascular angioplasty is a promising therapeutic strategy for FM-associated PVS. This protocol primarily outlines a stepwise approach to the transcatheter procedure for FM-associated PVS.
FAQs
Partial-pressure differences provide the driving force for gas diffusion at the alveoli. Oxygen moves from alveolar air into pulmonary capillaries, where its partial pressure is lower, while carbon dioxide moves in the opposite direction. This mechanism links ventilation with blood gas exchange and helps explain how disrupted alveolar conditions can affect oxygen delivery and carbon dioxide removal.
Airway resistance affects how easily air moves through the respiratory passages, whereas lung compliance describes how readily the lungs accommodate changes in volume. Together, these properties influence the effort and effectiveness of ventilation. Considering both helps clinicians understand why altered airway flow or reduced ease of lung expansion can change respiratory performance and treatment responses.
Ventilation-perfusion matching examines whether air delivery to the alveoli is appropriately coordinated with blood flow through the pulmonary capillaries. Effective matching supports efficient exchange of oxygen and carbon dioxide. Evaluating this relationship adds information beyond ventilation or perfusion alone, helping clinicians interpret impaired gas exchange and understand pulmonary changes associated with respiratory disorders.
Pulmonary physiology provides the framework for connecting pulmonary function test findings with underlying respiratory processes. Clinicians can consider ventilation, airway resistance, lung compliance, gas diffusion, and ventilation-perfusion relationships when assessing results. This interpretation supports recognition of respiratory disorders, evaluation of physiological impairment, and assessment of whether treatment is producing a meaningful change in function.
Its principles are particularly important in anesthesia, critical care, exercise assessment, and chronic lung disease. In these settings, clinicians and researchers must consider how ventilation, gas exchange, perfusion, and mechanical properties of the lungs interact. The same framework supports evaluation of normal responses, disease-related changes, and physiological responses to treatment across different clinical circumstances.
Pulmonary physiology allows treatment effects to be assessed by examining coordinated changes in airflow, lung mechanics, gas exchange, and blood flow through the lungs. Rather than focusing on one respiratory function in isolation, clinicians can evaluate how treatment influences the system as a whole. This approach helps determine whether physiological abnormalities are improving and informs ongoing clinical assessment.